学術変革領域研究(A)令和4〜8年度 自己指向性免疫学 生体防御における自己認識の「功」と「罪」
学術変革領域研究(A)令和4〜8年度 自己指向性免疫学 生体防御における自己認識の「功」と「罪」

Papers(論文)

■ 2026

Singh S, Islam SMS, Liu R, Adeniji OS, Simons LM, Saini P, Tateno H, Danesh A, Denton PW, Giron LB, Jones RB, Hultquist JF, Xiao H, Abdel-Mohsen M. HIV-induced sialoglycans on infected CD4+ T cells promote immune evasion from myeloid cell-mediated killing. Nat Commun 2026

Osada A, Tanaka M, Sugiura Y, Yuan X, Yamashita S, Ochi K, Kohda H, Ito A, Go S, Okajima T, Kadomatsu K, Yanagita M, Furuhashi K, Maruyama S, Suganami T. Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation. Sci Rep 2026

Itoh T, Tanaka HN, Pareek M, Nagae M, Manya H, Ido A, Mishra SK, Kizuka Y. Enzymatic basis of branching and extension of O-Man glycans for keratan sulfate biosynthesis. J Biol Chem 2026

Stifter SA, Bijnen M, Tuzlak S, Häne P, Roussel E, van Hove H, Asano K, Becher B, Keller A, Greter M. XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance. J Exp Med 2026

Kama Y, Hirano KI, Masuhara K, Endo Y, Fujimoto M, Matsuda T, Yahata T, Kato M, Hozumi K, Tanaka T, Hosokawa H. Notch interaction with RUNX factors regulates initiation of the T-lineage program. J Exp Med 2026

Abdelaal MR, Deng J, McInerney MP, Ito E, Purcell AW, Yamasaki S, Villadangos JA, McWilliam HEG, Gherardin NA, Rossjohn J, Awad W. The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites. J Exp Med 2026

Kurihara N, Isayama Y, Zhang J, Yamashita T, Awaji K, Ito Y, Yoshizaki A, Kouwaki T, Oshiumi H, Nishimasu H, Shibata M, Nureki O, Kato K. Molecular mechanism of MDA5 nucleation and filament formation by LGP2. Mol Cell 2026

Morita D, Fujii T, Inuki S, Suzuki H, Mikami B, Sugita M. Lipopeptide ligands captured by MHC class I molecules undergo dynamic conformational changes that affect their antigenic strength. J Biol Chem 2026

Heravizadeh O, Nakatani K, Tomiyasu N, Torigoe T, Yamashita T, Takahashi M, Izumi Y, Bamba T. Multi-condition machine learning models for understanding retention mechanisms and predicting retention time in supercritical fluid chromatography/mass spectrometry. Anal Chim Acta 2026

Torigoe S, Salie S, Keeton R, Aylan B, Appelmelk BJ, Williams DL, Lowman DW, Sugiki T, Matsumoto S, Kawano A, Mizuno S, Matsuo K, Søndergaard JN, Wing JB, Shoesmith R, Ndengane M, Coussens AK, Willment JA, Gutiérrez MG, Hoving JC, Yamasaki S, Brown GD. Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival. Sci Immunol 2026

Umakoshi Y, Izumi Y, Hashidate-Yoshida T, Shindou H, Bamba T. A widely targeted analytical method for oxylipins including enantiomers using chiral liquid chromatography tandem mass spectrometry. J Chromatogr A 2026

Moriuchi A, Izumi Y, Yamashita T, Takahashi M, Bamba T. Separation of homologues and positional isomers of secondary alcohol ethoxylates via supercritical fluid chromatography. J Chromatogr A 2026

Saini P, Mirji G, Shamsul Islam SMS, Simons LM, Bhat SA, Bonfanti AP, Muthumani K, Agrawal P, Cassel J, Tang HY, Tateno H, Zhang R, Hultquist JF, Shinde RS, Abdel-Mohsen M. Targeting Interactions Between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer. Cancer Res 2026

Keisham S, Burramsetty A, Oinam L, Kumano K, Shimomura O, Oda T, Tateno H. GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer. Adv Sci 2026

Fukui R, Murakami Y, Kanno A, Motoi Y, Manno A, Honda T, Yamada S, Ishiguro J, Kagari T, Nakamura K, Kadokura M, Isobe T, Tomimori Y, Tanaka J, Senaldi G, Shimizu T, Miyake K. Anti-human TLR7 antibody for therapeutic intervention in systemic lupus erythematosus. Int Immunol 38: 28-40 2026

Komiyama S, Kodaira Y, Maeda R, Sugiura Y, Suzuki K, Saeki A, Kinashi Y, Oguchi H, Takano K, Onawa S, Matsui A, Sasaki E, Hattori-Muroi K, Kimura S, Fujimura Y, Ka Y, Ogura T, Hanaoka K, Ito M, Watarai H, Kaisho T, Udagawa N, Takahashi D, Hase K. M cell–dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer’s patches. Proc Natl Acad Sci USA 2026

Lestari T, Yawata N, González G, Miyadera H, Motooka D, Imamura Y, Oki H, Mori Y, Shirane M, Khor SS, Omae Y, Shimada M, Windy DA, Nakano S, Tsutsui H, Kuramoto S, Fukui C, Nakamura R, Yamana S, Kaburaki T, Mashimo H, Takase H, Yanai R, Hasegawa E, Shibata K, Yawata M, Tokunaga K, Ohguro N, Sonoda KH. Molecular Variations in Glycoprotein B of Asian Human Cytomegalovirus: Potential Impact on Virus Entry and Immune Evasion in Ocular Diseases. J Med Virol 2026

Kanai-Azuma M, Asahara H, Yashiro K, Kanai Y. The Meeting Report on the VIIth International Workshop on SOX Transcription Factors. Genes Cells 2026

Nakahashi R, Matoba H, Sakai Y, Miura T, Moriyama T, Yoritate M, Yamasaki S, Hirai G. Linkage-Editing of 6,6′-Diacyl Neotrehalose and Evaluation of Mincle Activation Ability. Chem Asian J 2026

■ 2025

Miyako K, Kanno T, Endo T, Yoshida S, Iwao Y, Nakano K, Yokoyama S, Asou HK, Yamada K, Nakayama M, Ohara O, Endo Y. The RORγt ligand-binding domain controls the pathogenicity of IL-17A+ T cells differently in autoimmune diseases of the skin and CNS. Cell Rep 2025

Kiuchi M, Nemoto M, Yagyu H, Aoki A, Iwamura C, Sugimoto H, Masuo Y, Morita H, Ma S, Okuno Y, Hishiya T, Tsuji K, Sasaki A, Kokubo K, Ohishi K, Shinmi R, Sonobe Y, Iinuma T, Yonekura S, Yokomizo T, Komatsu N, Onodera A, Okumura S, Ito T, Hatano E, Tsuruyama T, Kurashima Y, Mato N, Suzuki T, Kimura MY, Motohashi S, Kawakami E, Ueno H, Tumes DJ, Hanazawa T, Nakayama T, Hirahara K. Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4+ T cells. Science 2025

Dewa KI, Kaseda K, Kuwahara A, Kubotera H, Yamasaki A, Awata N, Komori A, Holtz MA, Kasai A, Skibbe H, Takata N, Yokoyama T, Tsuda M, Numata G, Nakamura S, Takimoto E, Sakamoto M, Ito M, Masuda T, Nagai J. The astrocytic ensemble acts as a multiday trace to stabilize memory. Nature 2025

Sakaguchi K, Sugawara K, Hosokawa Y, Ito J, Morita Y, Mizuma H, Watanabe Y, Kimura Y, Aburaya S, Takahashi M, Izumi Y, Bamba T, Komada H, Yamada T, Hirota Y, Yoshida M, Nogami M, Murakami T, Ogawa W. Metformin-regulated glucose flux from the circulation to the intestinal lumen. Commun Med 2025

Roh T, Ju S, Park SY, Ahn Y, Chung J, Nakano M, Ryu G, Kim YJ, Kim G, Choi H, Lee SG, Kim IS, Lee SI, Chung C, Shimizu T, Miyoshi E, Jung SS, Park C, Yamasaki S, Jo EK. Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study. Nat Commun 2025

Shimizu H, Miyamoto J, Hisa K, Ohue-Kitano R, Takada H, Yamano M, Nishida A, Sasahara D, Masujima Y, Watanabe K, Nishikawa S, Takahashi S, Ikeda T, Nakajima Y, Yoshida N, Matsuzaki C, Kageyama T, Hayashi I, Matsuki A, Akashi R, Kitahama S, Ueyama M, Murakami T, Inuki S, Irie J, Satoh-Asahara N, Toju H, Mori H, Nakaoka S, Yamashita T, Toyoda A, Yamamoto K, Ohno H, Katayama T, Itoh H, Kimura I. Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides. Nat Commun 2025

Andoh M, Shinoda N, Taira Y, Araki T, Kasahara Y, Takeuchi H, Miura M, Ikegaya Y, Koyama R. 2025. Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia. Nat Commun 2025

Takao T, Matsui A, Kikutake C, Kan-O K, Inoue A, Suyama M, Okamoto I, Ito M. Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring. Nat Commun 2025

Hirano Y, Ezaki W, Sato R, Ohto U, Miyake K, Shimizu T. Mechanistic insights into single-stranded DNA degradation by lysosomal exonucleases PLD3 and PLD4 from structural snapshots. Nat Commun 2025

Kojima F, Morishita S, Uda S, Yutsudo N, Ogawa Y, Kubota H. Evaluation of the insulin-dependent and -independent hypoglycemic effects and understanding their breakdown in the progression of obesity using mice. PLOS ONE 2025

Amatsu S, Matsumura T, Morimoto C, Keisham S, Goto Y, Kohda T, Hirabayashi J, Kitadokoro K, Katayama T, Kiyono H, Tateno H, Zuka M, Fujinaga Y. Gut mucin fucosylation dictates the entry of botulinum toxin complexes. Nat Commun 2025

Tsubaru M, Hori S. Low ZAP70 expression drives neonatal Treg cell development. Nat Immunol 2025

Yanagihara Y, Takahashi M, Izumi Y, Kinoshita T, Takao M, Bamba T, Imai Y. Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes. Nat Commun 2025

Nishikawa T, Takeuchi A, MacHiyama H, Wakamatsu E, Nishijima H, Furuhata M, Toyota H, Nishi W, Matsushima R, Yoshida Y, Harada K, Yokosuka T. CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell functions via CAR-CD28 microclusters. Commun Biol 2025

Ohyagi M, Ito M, Iizuka-Koga M, Mise-Omata S, Yoshimura A. Stage-specific roles of clonally expanded CD8+ T cells in regulating amyloid pathology in Alzheimer’s disease models. Nat Commun 2025

Nibe-Shirakihara Y, Honda S, Arakawa S, Torii S, Tajima-Sakurai HT, Yamaguchi H, Oshima S, Okamoto R, Lazarou M, Kawakami H, Shimizu S. Optineurin is an adaptor protein for ubiquitinated substrates in Golgi membrane-associated degradation. Nat Commun 2025

Peng Y, Fujimura A, Asami J, Zhang Z, Shimizu T, Ohto U. Structural insights into Wnt/β-catenin signaling regulation by LGR4, R-spondin, and ZNRF3. Nat Commun 2025

Ishikawa E, Kosako H, Motooka D, Imasaka M, Ohmuraya M, Yamasaki S. Invariant TCR-triggered protein kinase D activation mediates NKT cell development. J Exp Med 2025

Baba Y, Maezawa Y, Kondo N, Minamizuka T, Udagawa H, Ide S, Ide K, Teramoto N, Yamaguchi A, Kaneko H, Funayama S, Kato H, Shoji M, Aono K, Miyabayashi M, Sato T, Kitamoto T, Yagyu Y, Ishibashi R, Koshizaka M, Endo Y, Kanda M, Takemoto M, Takayama N, Yasuda K, Kobayashi Y, Yokote K. Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling. Sci Rep 2025

Tsukamoto S, Tateno H, Shimomura O, Yamamoto K, Saito S, Murakami J, Nakahashi H, Miyazaki Y, Enomoto T, Oda T. Identification of CLEC10A as a human lectin for pancreatic ductal adenocarcinoma. Sci Rep 2025

Otsuka Y, Kabayama K, Miura A, Takahashi M, Hata K, Izumi Y, Bamba T, Fukase K, Toyoda M. Single-cell mass spectrometry imaging of lipids in HeLa cells via tapping-mode scanning probe electrospray ionization. Commun Chem 2025

Nishimura ES, Hishikawa A, Nakamichi R, Akashio R, Chikuma S, Hashiguchi A, Yoshimoto N, Hama EY, Maruki T, Itoh W, Yamaguchi S, Yoshino J, Itoh H, Hayashi K. DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages. Nat Commun 2025

Yahata T, Toujima S, Sasaki I, Iwahashi N, Fujino M, Nishioka K, Noguchi T, Tanizaki-Horiuchi Y, Kaisho T, Ino K. Adeno-associated virus-clustered regularly interspaced short palindromic repeats/cas9‑mediated ovarian cancer treatment targeting PD-L1. BMC Cancer 2025

Goto A, Komura S, Kato K, Maki R, Hirakawa A, Aoki H, Tomita H, Taguchi J, Ozawa M, Matsushima T, Kishida A, Kimura T, Asahara H, Imai Y, Yamada Y, Akiyama H. PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration. Nat Commun 2025

Ito T, Guenther C, Ishikawa E, Yabuki T, Nagae M, Nakatani Y, Yamasaki S. Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates. Immunogenetics 2025

Osuka RF, Nagae M, Nakano M, Tanigawa S, Ono K, Tsuji Y, Ito Y, Takahashi K, Nishinakamura R, Kizuka Y. Selective modification of glycoprotein substrates by GnT-V in mouse kidney. iScience 2025

Morigo A, Elin Teppa R, Nagae M, Yagi H, Kizuka Y, Harduin-Lepers A. Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families. iScience 2025

Kadariswantiningsih IN, Okunaga I, Yamasaki K, Empitu MA, Yamada H, Makino SI, Hotta A, Yagita H, Aizawa M, Koyama-Nasu R, Kimura MY, Tatsumoto N, Asanuma K. CCL5 paradoxically regulates glomerular injury by skewing macrophage polarization. JCI Insight 2025

Kanno T, Nakano K, Endo Y. Cellular metabolism in Th9, Th17, and Treg cell differentiation. Int Immunol 2025

Kondo H, Otsuka K, Morimoto J, Arimochi H, Tsukumo SI, Yasutomo K. Loss of Dmrta1 alters CD8þ T cell activation and resistance to influenza virus infection. ImmunoHorizons 2025

Inuki S, Ohno H. Visible-light-mediated Radical Dearomatization of N-(2-Phenyl)benzoyl Amino Acid Derivatives for the Construction of Spirocyclic and Bicyclic Frameworks. J Syn Org Chem 2025

Ibusuki M, Nakatani K, Matsuda Y, Umakoshi H, Yokomoto-Umakoshi M, Takayanagi H, Sakamoto R, Kawazoe T, Oki E, Yoshizumi T, Izumi Y, Bamba T, Ogawa Y. Plasma Steroid Profiles in Individuals With Class II/III Obesity: Association With Weight Loss After Metabolic Surgery. J Endocr Soc 2025

Kogue Y, Ikeda S, Maehara Y, Kawamoto R, Suga M, Kida S, Shibata K, Tsutsumi K, Murakami H, Mizuta E, Mizutani Y, Yamaguchi Y, Okuzaki D, Hosen N. CAR NK cell production from human cord blood NK progenitor cells is enhanced by stimulation of the IL-15 receptor. Cancer Immunol Immunother 2025

Hino A, Kusakabe S, Oka K, Kudo H, Ariyoshi T, Hayashi A, Takahashi M, Onizuka M, Takeda K, Mori M, Hosen N, Fukushima K. Enterococcus proliferates via the phosphotransferase system in the disrupted gut microbiota after allogeneic haematopoietic stem cell transplantation. Br J Haematol 2025

Kusakabe S, Kurashige R, Fukushima K, Shimizu K, Yoshihara T, Motooka D, Nakamura S, Kurashige M, Nakata K, Hino A, Kasahara H, Ueda T, Fujita J, Hosen N, Takehara T, Oda J. Fecal microbiota transplantation for Crohn’s disease-like intestinal lesions arising after allogeneic stem cell transplantation. Int J Hematol 2025

Nagano M, Hu B, Ogata K, Umemura F, Ishikura Y, Suzuki S, Katsifis CC, Yoshinaga M, Litos G, Nagasaka K, Tang W, Nosaka Y, Sasada H, Wang H, Kondo D, Katou Y, Mizuta K, Yabuta Y, Ohta H, de Luna Vitorino FN, Arima H, Ichikawa T, Gabriele M, Majewski J, Garcia BA, Takeuchi O, Yoshida S, Hansen AS, Peters JM, Ishihama Y, Saitou M. 2025. The mitotic STAG3–cohesin complex shapes male germline nucleome. Nat Struct Mol Biol 2025

Tomiyasu N, Izumi Y, Heraviadeh O, Takahashi M, Bamba T. Evaluation of separation performance and quantification accuracy in lipidomics methods. J Chromatogr A 2025

Susukida T, Aoki S, Hayakawa Y. Preferential Recognition of Drug-Induced Altered Self-Presentation on Tumor Cells, but Not Host Cells, by CD8+ T Cells for Eliciting Anti-Tumor Immunity. Biol Pharm Bull 2025

Odaka H, Tateno H. Single-cell glycome and transcriptome profiling uncovers the glycan signature of each cell subpopulation of human iPSC-derived neurons. Stem Cell Rep 2025

Yagyu H, Kiuchi M, Sasaki A, Itakura E, Kokubo K, Iwamura C, Onodera A, Aoki A, Hishiya T, Tsuji K, Hiramoto T, Shinmi R, Sonobe Y, Arano T, Ohishi K, Baba S, Kurita J, Iinuma T, Yonekura S, Hara Y, Kimura MY, Motohashi S, Tumes DJ, Hanazawa T, Kaneko T, Nakayama T, Hirahara K. Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity. Sci Immunol 2025

Hotta S, Matsunaga M, Miyake A, Takeda AK, Watanabe S, Hosen N, Hagihara K. Gut Microbiota Enterotype as a Predictor of Sarcopenia in the Japanese Elderly Population. Nutrients 2025

Arakawa S, Yamaguchi H, Shimizu S. Discovery of Golgi membrane-associated degradation (GOMED) pathway: a focus on 15 years of ultrastructural analyses. Microscopy 2025

Hayashi Y, Hino S, Sato T, Kashio S, Otsubo K, Saito K, Sato B, Kawano N, Saito D, Miura M, Suyama M, Nakao M, Kobayashi S. Repressive S-adenosylmethionine biosynthesis status inhibits transcription of HeT-A retrotransposon in the germline of Drosophila. J Biochem 2025

Hosoe S, Katakami N, Taya N, Omori K, Takahara M, Konya Y, Obara S, Hidaka A, Nakao M, Takahashi M, Izumi Y, Bamba T, Shimomura I. Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry. Diabetes 2025

Iida S, Ito S, Sunami K, Takamatsu H, Tsukada N, Hosen N, Miki H. JSH practical guidelines for hematological malignancies, 2023 III. Myeloma 1. Multiple myeloma (MM). Int J Hematol 2025

Iida S, Ito S, Sunami K, Takamatsu H, Tsukada N, Hosen N, Miki H, Fuchida SI, Sakaida E. JSH practical guidelines for hematological malignancies, 2023 III. Myeloma 2. Related disorders of multiple myeloma. Int J Hematol 2025

Murayama R, Horisawa K, Miura S, Taniguchi S, Shu J, Takahashi M, Izumi Y, Bamba T, Ishigami K, Suzuki A. Differential Effects of Liver Regeneration on Aging-Related Changes in Gene Expression and Metabolic Function. Aging Cell 2025

Nonaka D, Yoshida S, Nakano K, Li X, Okamura T, Umemoto E, Yamada T, Watanabe M, Jinno S, Ito M, Tsuda M, Noguchi N, Jiang JX, Sumiya E, Sawa S. Fibroblast-derived CSF1 maintains colonization of gut mucosal macrophage to resist bacterial infection. Mucosal Immunol 2025

Liu L, Chiba T, Matsushima T, Inotsume M, Kato T, Hiraoka Y, Asahara H. Gene dosage-dependent roles of Mkx in postnatal tendon development and maintenance revealed by conditional deletion. Dev Biol 2025

Yamasaki A, Shintaku H, Harada A, Maehara K, Tanaka K, Saeki M, Ito M, Konishi H, Tsuda M, Prinz M, Kishi Y, Ohkawa Y, Yamamoto S, Masuda T. Cyclin-dependent kinase inhibitor 1A mediates mouse line- and fate-dependent cellular responses in Cx3cr1-Cre genetic tools. Cell Reports 2025

Ozaki K, Aoki T, Kobayashi M, Takami M, Ito T, Ogawa K, Tanaka H, Nishii K, Nishimura K, Motoyoshi K, Kojima I, Katsumi D, Shimizu D, Wang H, Kimura MY, Hirahara K, Koseki H, Higuchi Y, Motohashi S. Anti-tumor effect of intratumoral administration of induced pluripotent stem cell-derived NKT cells on glioblastoma through CD155/DNAM-1 interaction. Stem Cells Transl Med 2025

Shimamoto N, Arichi N, Inuki S, Ohno H. Photoinduced Azidosulfonylative Cyclization of 1,6-Dienes with Sulfonyl Azides. Chem Pharm Bull 2025

Saiga H, Ueno M, Tamura T, Tsujimura Y, Asaka MN, Tsukamoto Y, Mukai T, Hamada M, Takahashi S, Tanaka T, Kaisho T, Takahashi Y, Hoshino K, Ato M. Mycobacterium tuberculosis impairs protective cytokine production via transcription factor MafB manipulation. PLOS Pathogens 2025

Xie Y, Huang Y, Chettiar V, Xing T, Huang SK, Moore BB, Asahara H, Abel PW, Tu Y. miR-146b disrupts the epidermal growth factor receptor/transforming growth factor β receptor profibrotic feedforward loop to inhibit lung fibroblast proliferation and differentiation. J Pharmacol Exp Ther 2025

Endo Y, Hasegawa I, Igi A, Onodera A, Mita S, Higashi K, Kurokawa K, Toyoda A, Kiuchi M, Shinzawa M, Wang Y, Koyama-Nasu R, Hirahara K, Motohashi S, Nakayama T, Kimura MY. SLAMF6 regulates basal T cell receptor signaling and influences invariant natural killer T cell lineage diversity. Int Immunol 2025

Tsuchiya Y, Matsuo H, Asahara H, Inui M. Matrix stiffness regulates Mkx expression in rat tenocyte through TRPM7. Biochem Biophys Rep 2025

Nakagawa T, Hata K, Izumi Y, Nakashima H, Katada S, Matsuda T, Bamba T, Nakashima K. E3 ubiquitin ligase RMND5A maintains the self-renewal state of human neural stem/precursor cells by regulating Wnt and mTOR signaling pathways. FEBS Lett 2025

Natsume-Kitatani Y, Kobiyama K, Igarashi Y, Aoshi T, Nakatsu N, Tripathi LP, Ito J, Nyström-Persson J, Kosugi Y, Allendes Osorio RS, Nagao C, Temizoz B, Kuroda E, Standley DM, Kiyono H, Nakanishi K, Uematsu S, Hamaguchi I, Yasutomi Y, Kunisawa J, Yamasaki S, Coban C, Yamada H, Mizuguchi K, Ishii KJ. An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics. Cell Chem Biol 2025

Arai J, Hayakawa Y, Suzuki N, Kinoshita H, Hata M, Kurokawa K, Matsushita Y, Abe S, Oya Y, Tsuboi M, Ihara S, Iwata Y, Murakami K, Shiokawa T, Shiomi C, Uekura C, Yamamoto K, Fujiwara H, Kawamura S, Nakagawa H, Ikenoue T, Tateno H, Ushiku T, Ijichi H, Hirata Y, Kasuga M, Su GH, Wang TC, Fujishiro M. ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment. iScience 2025

Matsuo-Dapaah J, Alshaweesh J, Lee MSJ, Hayashi T, Dash R, Kuroda M, Tainaka K, Ozawa M, Kuratani A, Yamamoto M, Liu K, Fukui R, Miyake K, Kobiyama K, Renia L, Ishii KJ, Coban C. IFNγ-inducible Gbp4 and Irgb6 contribute to experimental cerebral malaria pathology in the olfactory bulb. mBio 2025

Schutt CR, Birol D, Lu X, Yamasaki S. The presenting HLA determines fidelity of SARS-CoV-2 spike protein epitope prediction. Vaccine 2025

Zhang F, Celis-Gutierrez J, Zhang L, Mellado V, Gelard L, Panigot S, Mori D, Lu L, Voisinne G, Vilarnau Wolek C, Mello M, Burlet-Schiltz O, Gonzalez-De-Peredo A, Di Fioré F, Roncagalli R, Liang Y, Malissen M, Malissen B. A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo. J Exp Med 2025

Suzuki E, Serata M, Sako T, Sato S, Iino T, Tateno H, Hirabayashi J. Glycophenotyping of mutants of Lacticaseibacillus paracasei by lectin microarray. Appl Environ Microbiol 2025

Miyake K, Shibata T, Sato R, Fukui R. Innate immune responses to lysosomal nucleic acid stress. J Biochem 2025

Shinebaatar E, Morimoto J, Koga R, Nguyen TN, Sasaki Y, Yonemura S, Kosako H, Yasutomo K. Proteasome dysfunction in T cells causes immunodeficiency via cell cycle disruption and apoptosis. Int Immunol 2025

Enomoto M, Ohsawa S. “Cancer progression through systemic signaling viewed from Drosophila”. Curr Opin Cell Biol 2025

Ishikawa J, Kato K, Kannan S, Okazaki S, Ishiguro S, Yamashita K, Yachie N, Nishizawa T, Zhang F, Nishimasu H. Structural insights into RNA-guided RNA editing by the Cas13b–ADAR2 complex. Nat Struct Mol Biol 2025

Miyamoto N, Yoshida M, Tsukumo SI, Ogawa H, Otani T, Yasutomo K, Takizawa H. Enhancement of anti-programmed cell death protein-1 immunotherapy in non-small cell lung cancer using arginine and citrulline supplementation. J Thorac Dis 2025

Wada E, Hosono H, Tanaka M, Miyakawa F, Ochi K, Kohda H, Tanno S, Shimano R, Ito A, Kitaura Y, Ichihara K, Matsumoto A, Ogi T, Satoh-Asahara N, Murohara T, Suganami T. Transient Dietary Intervention Induces Healthy Adipose Tissue Expansion and Metabolically Healthy Obesity in Mice. FASEB Journal 2025

Shigematsu K, Matsuda K, Nabekura T, Kanemaru K, Shibuya K, Tateno H, Shibuya A. Tn antigen suppresses lipopolysaccharide-induced dermatitis via Clec10a. Biochem Biophys Res Commun 2025

Ohno H, Tsuji A, Hasegawa D, Inuki S, Arichi N. Synthetic Study of Caulerpin: Construction of the Core Structure through Gold-Catalyzed Cascade Cyclization of Azido-Alkynes. Chem Pharm Bull 2025

Ishii Y, Shiota A, Takao T, Yamamoto N, Ogawa T, Jo A, Shinozaki S, Fukuyama S, Koga T, Ito M, Tanaka H, Tamura A, Tsukita S, Matsumoto K, Okamoto I, Kan-O K. Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model. Allergol Int 2025

Suzuki H, Kunimatsu Y, Yoshioka Y, Asa M, Yamasaki S, Sugita M, Morita D. TAP-independent induction of N-myristoylated lipopeptide-specific CTLs in transgenic mice expressing the rhesus MHC class I allomorph, Mamu-B*098. J Immunol 2025

Taya N, Katakami N, Omori K, Hosoe S, Watanabe H, Takahara M, Miyashita K, Konya Y, Obara S, Hidaka A, Nakao M, Takahashi M, Izumi Y, Bamba T, Shimomura I. Plasma Diacylglycerols Are Associated with Carotid Intima-Media Thickness Among Patients with Type 2 Diabetes: Findings from a Supercritical Fluid Chromatography/Mass Spectrometry-Based Semi-Targeted Lipidomic Analysis. Int J Mol Sci 2025

Ueda Y, Obara N, Ueno S, Sakurai M, Hosokawa K, Murata T, Fukuoka Y, Hayama N, Yamashita M, Ogawa Y, Usuki K, Ikezoe T, Kawaguchi T, Hosen N, Kanakura Y, Gotoh A, Nishimura JI. Treatment burden in patients with paroxysmal nocturnal hemoglobinuria: an in-depth interview survey. Ann Hematol 2025

Ito E, Yamasaki S. Diversity and hallmarks of metabolites surveyed by MR1. Immunobiology 2025

Kohda H, Tanaka M, Shichino S, Arakawa S, Komori T, Ito A, Wada E, Ochi K, Yuan X, Takeda T, Saiki A, Tatsuno I, Ikeda K, Miyai Y, Enomoto A, Morikawa Y, Shimizu S, Ueha S, Matsushima K, Ogawa Y, Suganami T. Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis. Diabetes 2025

Kashio S, Miura M. S-adenosylmethionine metabolism buffering is regulated by a decrease in glycine N-methyltransferase via the nuclear ubiquitin–proteasome system. Proc Natl Acad Sci USA 2025

Iwamoto N, Ohno S, Nakamura K, Naito T, Miura S, Inuki S, Ohno H, Hayashi G, Murakami H, Oishi S. Design and Evaluation of Stable Cysteine-Modified Monobody Scaffolds for Mirror-Image Synthesis. Bioconj Chem 2025

Muro R, Nitta T. It's Time to Unite: Diversity and Coordination of Thymic Stromal Cells for T Cell Selection and Organ Integrity. Immunol Rev 2025

Iguchi E, Takai A, Oe N, Fujii Y, Omatsu M, Takeda H, Shimizu T, Maruno T, Nakanishi Y, Yoshinaga M, MaruYama T, Marusawa H, Obama K, Takeuchi O, Seno H. Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA. Proc Natl Acad Sci USA 2025

Takii T, Yamada H, Motozono C, Yamasaki S, Torrelles JB, Turner J, Kimishima A, Asami Y, Ohara N, Hida S, Hayashi H, Onozaki K. Mycobacterium tuberculosis bacillus induces pyroptosis in human lung fibroblasts. mSphere 2025

Yang Z, Li J, Watanabe H, Gao F, Kawajiri A, Koinuma K, Sato K, Okuyama Y, Tayama S, Iwakura Y, Ishii N, Kawabe T. Naturally Arising Memory-Phenotype CD4+ T Lymphocytes Give Rise to Multiple Helper Subsets to Contribute to Tumor Immunity while Inhibiting GVHD. Cancer Immunol Res 2025

Lu T, Umeshita S, Imanishi K, Wang Y, Liu YS, Nagae M, Senoo Y, Ikeda K, Fujita M, Kinoshita T, Murakami Y. ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis. J Biol Chem 2025

Kobayashi Y, Sato R, Shimizu Y, Fukui R, Shibata T, Tsukamoto H, Tsubata T, Miyake K. CD20 and CD19 promote proliferation driven by the IgM-TLR9-L265P MyD88 complex. Int Immunol 2025

Tanaka R, Murakami Y, Ellis D, Seita J, Yinga W, Kakuta S, Kumano K, Fukui R, Miyake K. TLR7 responses in glomerular macrophages accelerate the progression of glomerulonephritis in NZBWF1 mice. Int Immunol 2025

Zhang Z, Shimizu T. Recent advances in structural studies of NLRP3 and NLRP1 inflammasome regulation. Curr Opin Struct Biol 2025

Koyama-Nasu R, Wang Y, Miyano H, Kimura MY. Differentiation of Cytotoxic CD8+ T Cell Subsets Under Tumor Progression: Can CD69 Be a New Therapeutic Target? Cancer Sci 2025

van Hove H, Glück C, Mildenberger W, Petrova E, Maheshwari U, Häne P, Kreiner V, Bijnen M, Mussak C, Utz SG, Droux J, Ingelfinger F, Ashworth C, Stifter SA, Roussel E, Lelios I, Vermeer M, Huang SF, Zhou Q, Chen Z, Calvet C, Bourgeois S, Schaffenrath J, Razansky D, Juang JX, Asano K, Pelczar P, Mundt S, Weber B, Wegener S, Tugues S, Stockmann C, Becher B, Keller A, El Amki M, Greter M. Interleukin-34-dependent perivascular macrophages promote vascular function in the brain. Immunity 2025

Nagasaki M, Hirayasu K, Khor SS, Otokozawa R, Sekiya Y, Kawai Y, Tokunaga K. JoGo-LILR caller: Unveiling and navigating the complex diversity of LILRB3-LILRA6 copy number haplotype structures with whole-genome sequencing. Hum Immunol 2025

Chida S, Chiba T, Uchida Y, Matsushima T, Kurimoto R, Miyazaki T, Yagasaki L, Nakamura S, Mihara E, Takagi J, Moriyama K, Asahara H. Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement. J Bone Miner Metab 2025

Takeuchi Y, Ishikawa E, Sato T, Shinkai M, Takahashi Y, Lu X, Yamasaki S. Analysis of antigen specificity of Treg clonotypes expanded upon SARS-CoV-2 infection. Int Immunol 2025

Morito M, Hata K, Izumi Y, Bamba T, Matsumori N. Comprehensive Identification of Lipid-Membrane Protein Interactions via Advanced Proteomics and Extended Lipid-Immobilized Bead Technology. Anal Chem 2025

Morita K, Hatano A, Kokaji T, Sugimoto H, Tsuchiya T, Ozaki H, Egami R, Li D, Terakawa A, Ohno S, Inoue H, Inaba Y, Suzuki Y, Matsumoto M, Takahashi M, Izumi Y, Bamba T, Hirayama A, Soga T, Kuroda S. Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in healthy and obese mouse liver. Sci Signal 2025

Jobin K, Seetharama D, Rüttger L, Fenton C, Kharybina E, Wirsching A, Huang A, Knöpper K, Kaisho T, Busch DH, Vaeth M, Saliba AE, Graw F, Pulfer A, F. Gonzalez SF, Zehn D, Liang Y, Ugur M, Gasteiger G, Kastenmüller W. A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals. Science 2025

Laporte M, Jochmans D, Bardiot D, Desmarets L, Debski-Antoniak OJ, Mizzon G, Abdelnabi R, Leyssen P, Chiu W, Zhang Z, Nomura N, Boland S, Ohto U, Stahl Y, Wuyts J, de Jonghe S, Stevaert A, Van Hemert MJ, Bontes BW, Wanningen P, Groenewold GJM, Zegar A, Owczarek K, Joshi S, Koukni M, Arzel P, Klaassen H, Vanherck JC, Vandecaetsbeek I, Cremers N, Donckers K, Francken T, van Buyten T, Rymenants J, Schepers J, Pyrc K, Hilgenfeld R, Dubuisson J, Bosch BJ, van Kuppeveld F, Eydoux C, Decroly E, Canard B, Naesens L, Weynand B, Snijder EJ, Belouzard S, Shimizu T, Bartenschlager R, Hurdiss DL, Marchand A, Chaltin P, Neyts J. A coronavirus assembly inhibitor that targets the viral membrane protein. Nature 2025

Tateno H, Mahal LK, Feizi T, Kettner C, Paulson JC. The minimum information required for a glycomics experiment (MIRAGE) project: Improving the standards for reporting lectin microarray data. Glycobiology 2025

Ito J, Miyake K, Chiba T, Takahashi K, Uchida Y, Blackshear PJ, Asahara H, Karasuyama H. Tristetraprolin-mediated mRNA destabilization regulates basophil inflammatory responses. Allergol Int 2025

Tani-Ichi S, Abe S, Miyachi H, Kitano S, Shimba A, Ejima A, Hara T, Cui G, Kado T, Hori S, Tobe K, Ikuta K. IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis. J Immunol 2025

Watanabe T, Nagai M, Ishibashi Y, Iwasaki M, Mizoguchi M, Nagata M, Imai T, Takato K, Imamura A, Kakuta Y, Teramoto T, Tani M, Matsuda J, Ishida H, Yamasaki S, Okino N, Ito M. Vacuolar sterol β-glucosidase EGCrP2/Sgl1 deficiency in Cryptococcus neoformans: Dysfunctional autophagy and Mincle-dependent immune activation as targets of novel antifungal strategies. PLOS Pathogens 2025

Ikeda S, Hasegawa K, Kogue Y, Arimori T, Kawamoto R, Wibowo T, Yaga M, Inada Y, Uehara H, Matsubara M, Tachikawa M, Suga M, Kida S, Shibata K, Tsutsumi K, Fukushima K, Fujita J, Ueda T, Kusakabe S, Hino A, Ichii M, Hirose A, Nakamae H, Hino M, Nakao T, Inoue M, Yoshihara K, Yoshihara S, Ueda S, Tachi T, Kuroda H, Murakami K, Kijima N, Kishima H, Igashira E, Murakami M, Takiuchi T, Kimura T, Hiroshima T, Shintani Y, Imai C, Yusa K, Mori R, Ogino T, Eguchi H, Takeda K, Oji Y, Kumanogoh A, Takagi J, Hosen N. CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant. Nature Cancer 2025

Ito R, Sumitomo R, Iizawa M, Yanai H, Ono R. Inhibitory effect of streamer discharge on the local recurrence of B16F10 melanoma tumor in mice. J Phys D: Appl Phys 2025

Watanabe K, Yamano M, Miyamoto J, Ohue-Kitano R, Masujima Y, Sasahara D, Mouri Y, Kono N, Inuki S, Osakada F, Nagaoka K, Aoki J, Sugiura Y, Ohno H, Kondoh E, Kimura I. Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state. Cell Rep 2025

Matsuoka T, Takasaki R, Akiba H, Ogata K, Hattori A, Arichi N, Kakeya H, Yamasaki S, Ishihama Y, Ohno H, Inuki S. Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling. Chem Commun 2025

Sakai Y, Asa M, Hirose M, Kusuhara W, Fujiwara N, Tamashima H, Ikazaki T, Oka S, Kuraba K, Tanaka K, Yoshiyama T, Nagae M, Hoshino Y, Motooka D, Van Rhijn I, Lu X, Ishikawa E, Moody DB, Kato T, Inuki S, Hirai G, Yamasaki S. A conserved human CD4+T cell subset recognizing the mycobacterial adjuvant trehalose monomycolate. J Clin Invest 2025

Ueki K, Nozawa R, Matsumaru T, Yamasaki S, Fujimoto Y. 2025. Lipid structure-dependent CD1d functional stabilization and immunomodulation of endogenous glucosylceramides. Chem Commun 2025

Yokomoto-Umakoshi M, Fujita M, Umakoshi H, Ogasawara T, Iwahashi N, Nakatani K, Kaneko H, Fukumoto T, Nakao H, Haji S, Kawamura N, Shimma S, Seki M, Suzuki Y, Izumi Y, Oda Y, Eto M, Ogawa S, Bamba T, Ogawa Y. Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone-producing adenomas with KCNJ5 mutations. Proc Natl Acad Sci USA 2025

Kim HD, Jung S, Bang YH, Kim J, Kim HJ, Lee HE, Hyung J, Yoo C, Kim WT, Yoon MJ, Lee H, Ryou JH, Jeon H, Yanai H, Lee JS, Lee G, Ryu MH. Blood TCTP as a potential biomarker associated with immunosuppressive features and poor clinical outcomes in metastatic gastric cancer. J ImmunoTher Cancer 2025

Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K. RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med 2025

Sakabe R, Onishi K, Mochizuki J, Toshimitsu T, Shimazu T, Kishino S, Ogawa J, Yamasaki S, Sashihara T. Regulation of IL-10 production in dendritic cells is controlled by the co-activation of TLR2 and Mincle by Lactiplantibacillus plantarum OLL2712. Microbiol Spectr 2025

Nagae M. Commentary on ‘Structural insights into a bacterial β-glucosidase capable of degrading sesaminol triglucoside to produce sesaminol: towards the understanding of the aglycone recognition mechanism by the C-terminal lid domain’. J Biochem 2025

Kuroda H, Kijima N, Tachi T, Ikeda S, Murakami K, Nakagawa T, Yaga M, Nakagawa K, Utsugi R, Hirayama R, Okita Y, Kagawa N, Hosen N, Kishima H. Prostaglandin F2 receptor negative regulator as a potential target for chimeric antigen receptor-T cell therapy for glioblastoma. Cancer Immunol Immunother 2025

Miyata Y, Nishimura M, Nagata A, Jing X, Sultan CS, Kuribayashi R, Takahashi K, Lee Y, Nishizawa T, Segawa K. Membrane structure-responsive lipid scramblase activity of the TMEM63/OSCA family. FEBS Lett 2025

Suzuki K, Watanabe N, Torii S, Arakawa S, Ochi K, Tsuchiya S, Yamada K, Kawamura Y, Ota S, Komatsu N, Shimizu S, Ando M, Takaku T. BCR::ABL1-induced mitochondrial morphological alterations as a potential clinical biomarker in chronic myeloid leukemia. Cancer Sci 2025

Sawayama R, Minoda M, Kojima H, Okabe T, Isayama Y, Kato K, Nishimasu H, Urano Y, Komatsu T. Application of Intramolecular O-to-N Phosphoryl Transfer Reaction to Design Fluorogenic Probes to Detect Activities of Enzymes That Metabolize Short Peptides and Acylamino Acids. ACS Sensors 2025

Chua YC, Draper SL, Le S, de Menezes MN, Ganley M, Ge Z, Lee A, Phabmixay T, Hirschmann D, Robinson SA, Tan PS, Tullett KM, Anderson RJ, Jayasinghe D, Cozijnsen A, Lahoud MH, Caminschi I, Beattie L, McFadden GI, Larsen DS, Kaisho T, Gras S, Hermans IF, Compton BJ, Heath WR, Painter GF, Holz LE. Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination. Cell Rep 2025

Takahara A, Nakatsu T, Hirata K, Hayashi H, Kawaji K, Aoki K, Inuki S, Ohno H, Kato H, Kodama E, Oishi S. Elucidation of Postfusion Structures of the Measles Virus F Protein for the Structure-Based Design of Fusion Inhibitors. J Med Chem 2025

Zhang Z, Kasai S, Sakaniwa K, Fujimura A, Ohto U, Shimizu T. The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL. Structure 2025

Hosono Y, Tomiyasu N, Kasai H, Ishikawa E, Takahashi M, Imamura A, Ishida H, Compostella F, Kida H, Kumanogoh A, Bamba T, Izumi Y, Yamasaki S. Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells. J Exp Med 2025

Ishii N, Tateno H. Preparation of Small Extracellular Vesicles Using Sequential Ultrafiltration with Regenerated Cellulose Membranes of Different Molecular Weight Cutoffs: A Study of Morphology and Size by Electron Microscopy. Microsc Microanal 2025

Nihei Y, Kitamura D. Pathogenesis of IgA nephropathy as a tissue-specific autoimmune disease. Int Immunol 2025

Iijima A, Matsuda K, Yamasaki S, Shibuya K, Shibuya A. Clec12b Alleviates Mite-Induced Dermatitis by Regulating P2RX7-Mediated Mast Cell Activation in Mice. Allergy 2025

Nakata K, Akuta K, Endo T, Koike M, Motooka D, Okuzaki D, Kato H, Tomiyama Y, Hosen N, Kashiwagi H. A nonactivating ITGB3 mutation in the β3 cytoplasmic region causes macrothrombocytopenia with an impaired αIIbβ3/RhoA pathway. Blood Vessel Thromb Hemost 2025

Oi A, Shinoda N, Nagashima S, Miura M, Obata F. A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules. Cell Rep 2025

Sueyoshi K, Kishi J, Inuki S, Matsumaru T, Fujimoto Y. Highly Selective Cytokine Induction of Nitrated Lipid-Modified α-GalCer Derivatives Demonstrating High Binding Affinity to the Lipid Antigen Presenting Molecule CD1d. Chem Eur J 2025

Matsushima R, Wakamatsu E, MacHiyama H, Nishi W, Yoshida Y, Nishikawa T, Toyota H, Furuhata M, Nishijima H, Takeuchi A, Suzuki M, Yokosuka T. Imaging of biphasic signalosomes constructed by checkpoint receptor 2B4 in conventional and chimeric antigen receptor-T cells. iScience 2025

Hasegawa D, Tsuji A, Greiner LC, Arichi N, Inuki S, Ohno H. Synthesis of Azocine-Fused Indoles via Gold(I)-Catalyzed Cyclization of Azido-alkynes. J Org Chem 2025

Wu CC, Okano K, Religia P, Soma Y, Takahashi M, Izumi Y, Bamba T, Honda K. Combination of Two-Stage Continuous Feeding and Optimized Synthetic Medium Increases Lipid Production in Lipomyces starkeyi. Eng Life Sci 2025

Takeda H, Izumi Y, Bamba T. Quantitative Lipidomics of Biological Samples Using Supercritical Fluid Chromatography Mass Spectrometry. Methods Mol Biol 2025

Salim E, Hori A, Matsubara K, Takano-Shimizu-Kouno T, Pratomo AR, Marianne M, Syahputra A, Husori DI, Inoue A, Abdullah MA, Shamsudin NF, Rullah K, Kuraishi T. Detection of Human GPCR Activity in Drosophila S2 Cells Using the Tango System. Int J Mol Sci 2025

Bao W, Yamasaki T, Nakano M, Nagae M, Kizuka Y. Functions of unique middle loop and C-terminal tail in GnT-III activity and secretion. BBA Gen Subj 2025

Ohshima K, Torii S, Shimizu S. Presence of Gut Microbiota Worsens D-Galactosamine and Lipopolysaccharide-Induced Hepatic Injury in Mice. Genes Cells 2025

Wu Q, Ito M, Fujii T, Tanaka K, Nakatani K, Izumi Y, Bamba T, Baba T, Maehara K, Tomimatsu K, Takemoto T, Ohkawa Y, Harada A. Defects in the H3t Gene Cause an Increase in Leydig Cells With Impaired Spermatogenesis in Mice. Genes Cells 2025

Morimoto S, Tanaka Y, Nakata J, Fujiki F, Hasegawa K, Nakajima H, Nishida S, Tsuboi A, Hosen N, Kagawa N, Maruno M, Myoui A, Enomoto T, Izumoto S, Sekimoto M, Hashimoto N, Yoshimine T, Kumanogoh A, Oji Y, Oka Y, Sugiyama H. Spontaneous high clonal expansion of Wilms’ tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms’ tumor gene 1-expressing solid tumor. Cancer Immunol Immunother 2025

Ishida H, Yo R, Zhang Z, Shimizu T, Ohto U. Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms. FEBS Lett 2025

Miyata Y, Takahashi K, Lee Y, Sultan CS, Kuribayashi R, Takahashi M, Hata K, Bamba T, Izumi Y, Liu K, Uemura T, Nomura N, Iwata S, Nagata S, Nishizawa T, Segawa K. Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution. Nat Struct Mol Biol 2025

Kanayama D, Terasaka N, Kato K, Okazaki S, Suga H. A Nonviral Neo-Nucleocapsid for Cell-Specific RNA Delivery Developed by Pseudo-Cyclic Peptide Grafting and Directed Evolution. Angew Chem Int Ed 2025

Kanno T, Miyako K, Endo Y. The diverse interaction of metabolism, immune response, and viral pathogens. Front Immunol 2025

Aihara R, Takahashi M, Morino K, Matsubara K, Kunimura K, Nishikimi A, Izumi Y, Bamba T, Fukui Y, Uruno T. Phospholipase D1 is a critical mediator of neutrophil extracellular trap formation and venous thrombosis. Front Immunol 2025

Morino K, Akiyoshi S, Matsubara K, Sugiura Y, Izumi Y, Yotsumoto S, Yamamura K, Maeda R, Takahashi M, Nakata K, Bamba T, Nakahara T, Sakata D, Uruno T, Fukui Y, Kunimura K. Sulfotransferase SULT2B1 contributes to the epithelial–immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis. Front Immunol 2025

Inuki S. Functional Analysis of Archaeal Glyceroglycolipids and Their Application to Drug Discovery Fields. Trend Glycosci Glycotechnol 2025

Izumi M, Hano K, Kato T, Hirata A, Thaw P, Seki A, Tanaka M, Ochi K, Suganami T, Kitagawa H, Takasu M. Glucose and insulin responses following streptozotocin administration for the induction of a type 1 diabetes mellitus model in Microminipig. J Vet Med Sci 2025

Yoshikawa FSY, Yabe R, Torigoe S, Yamasaki S, Saijo S. The C-type lectin receptor Dcir (Clec4a2) restrains Aspergillus fumigatus elimination by limiting the degranulatory activity of neutrophils. Front Immunol 2025

Kanno T, Nakano K, Iwao Y, Endo Y. Multi-omics approach to dissect the significance of lipid metabolism in helper T cell subset. Front Immunol 2025

Asahara H. Molecular basis of individual locomotor function: Integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system. Proc Jpn Acad Ser B 2025

Kurosaka S, Tanno H, Hirose M, Kamada W, Takayashiki R, Sone I, Sato Y, Watanabe T, Ishi S, Shoji M, Imai Y, Sato K, Ishii K, Hara H, Yamasaki S, Saijo S, Iwakura Y, Kawakami K, Kanno E. Contribution of CARD9 signaling to wound healing in skin promoted by topical administration of heat-killed Enterococcus faecalis strain KH2 and the involvement of Dectin-2. Front Immunol 2025

Tayama S, Kitamura Y, Hiraide K, Suzuki H, Li J, Yang Z, Mitsuwaka R, Kawajiri A, Sato K, Gao F, Nakai T, Okuyama Y, Numakura T, Yamada M, Ida T, Morita M, Kawabe T, Akaike T, Ishii N. Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation. Front Immunol 2025

Okayama Y, Takakuwa T, Shimura Y, Imada K, Kosugi S, Hotta M, Fuchida SI, Tanaka H, Uoshima N, Yoshihara S, Kanda J, Shibayama H, Fukushima K, Ohta K, Yagi H, Ito T, Shimazaki C, Matsumura I, Takaori-Kondo A, Hosen N, Hino M, Kuroda J. Insights into very elderly multiple myeloma treatment from Kansai Myeloma Forum. Hematology 2025

Khor SS, Hirayasu K, Kawai Y, Kim HL, Nagasaki M, Tokunaga K. LILR genotype imputation with attribute bagging (LIBAG): leukocyte immunoglobulin-like receptor copy number imputation system. Front Immunol 2025

Matsushima T, Naito Y, Chiba T, Kurimoto R, Itano K, Ochiai K, Takahashi K, Goshima N, Asahara H. Localizatome: A database for stress-dependent subcellular localization changes in proteins. Database 2025

Fujitani M, Lu X, Shinnakasu R, Inoue T, Kidani Y, Seki NM, Ishida S, Mitsuki S, Ishihara T, Aoki M, Suzuki A, Takahashi K, Takayama M, Ota T, Iwata S, Shibata RY, Sonoyama T, Ariyasu M, Kitano A, Terooatea T, Kelly Villa J, Yamashita K, Yamasaki S, Kurosaki T, Omoto S. Longitudinal analysis of immune responses to SARS-CoV-2 recombinant vaccine S-268019-b in phase 1/2 prime-boost study. Front Immunol 2025

■ 2024

Ekimoto T, Nomura M, Saito Y, Suzuki M, Yamane T, Zhang Z, Ohto U, Ikeguchi M, Shimizu T. Synergistic Activation of TLR7 and 8 Mediated by Reduction of Electrostatic Repulsion. Chem Pharm Bull (Tokyo) 2024

Fujioka K, Nagai T, Hattori T, Kagami S, Yasutomo K, Galjart N, Hirayama T, Kawachi H, Urushihara M Renin-angiotensin blockade ameliorates the progression of glomerular injury in podocyte-specific Ctcf knockout mice. Nephrology (Carlton) 2024

Hasegawa K, Fujimori H, Nakatani K, Takahashi M, Izumi Y, Bamba T, Nakamura-Shima M, Shibuya-Takahashi R, Mochizuki M, Wakui Y, Abue M, Iwai W, Fukushi D, Satoh K, Yamaguchi K, Shindo N, Yasuda J, Asano N, Imai T, Asada Y, Katori Y, Tamai K. Delta-6 desaturase FADS2 is a tumor-promoting factor in cholangiocarcinoma. Cancer Sci 2024

Hattori K, Tanaka S, Hashiba D, Tamura J, Etori K, Kageyama T, Ito T, Meguro K, Iwata A, Suto A, Suzuki K, Nakamura J, Ohtori S, Ziegler SF, Nakajima H. Synovial regulatory T cells expressing ST2 deteriorate joint inflammation through the suppression of immunoregulatory eosinophils.J Autoimmun 2024

Hirano Y, Shimizu T. Structural Perspective of the Double-Stranded RNA Transport Mechanism by SID-1 Family Proteins.Biol Pharm Bull 2024

Hosen N. Designer immune cells.Inflamm Regen 2024

Ishihara T, Kato K, Matsumoto K, Tanaka M, Hara A, Shiraki Y, Morisaki H, Urano Y, Ando R, Ito K, Mii S, Esaki N, Furuhashi K, Takefuji M, Suganami T, Murohara T, Enomoto A. Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis.Genes Cells 2024

Kanno T, Miyako K, Endo Y. Lipid metabolism: a central modulator of RORγt-mediated Th17 cell differentiation. Int Immunol 2024

Kusumoto Y, Ueda M, Hashimoto M, Takeuchi H, Okada N, Yamamoto J, Nishii A, Fujino A, Kurahashi A, Satoh M, Iwasa Y, Okamura K, Obazaki K, Kumagai R, Sakamoto N, Tanaka Y, Kamiya Y, Hoshida T, Kaisho T, Hemmi H, Katakai T, Honda T, Kikuta J, Kataoka K, Ikebuchi R, Moriya T, Adachi T, Watanabe T, Ishii M, Miyawaki A, Kabashima K, Chtanova T, Tomura M. Sublingual immune cell clusters and dendritic cell distribution in the oral cavity. JCI Insight 2024

Mitchell JS, Spanier JA, Dwyer AJ, Knutson TP, Alkhatib MH, Qian G, Weno ME, Chen Y, Shaheen ZR, Tucker CG, Kangas TO, Morales MS, Silva N, Kaisho T, Farrar MA, Fife BT. CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes. Immunity 2024

Nakajima T, Kanno T, Ueda Y, Miyako K, Endo T, Yoshida S, Yokoyama S, Asou HK, Yamada K, Ikeda K, Togashi Y, Endo Y. Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling. Cell Mol Immunol 2024

Osa S, Enoki Y, Takahashi D,Chuang VTG, Taguchi K, Matsumoto K. T-cell immunosuppression in sepsis is augmented by sciatic denervation-induced skeletal muscle atrophy. FEBS Lett 2024

Osada N, Mishra SK, Nakano M, Tokoro Y, Nagae M, Doerksen RJ, Kizuka Y. Self-regulation of MGAT4A and MGAT4B activity toward glycoproteins through interaction of lectin domain with their own. iScience 2024

Osada N, Nagae M, Yamasaki T, Harduin-Lepers A, Kizuka Y. Regulation of human GnT-IV family activity by the lectin domain. Carbohydr Res 2024

Satoh T, Yagi-Utsumi M, Ishii N, Mizushima T, Yagi H, Kato R, Tachida Y, Tateno H, Matsuo I, Kato K, Suzuki T, Yoshida Y. Structural basis of sugar recognition by SCF. FEBS Lett 2024

Tabata S, Matsuda K, Soeda S, Nagai K, Izumi Y, Takahashi M, Motomura Y, Ichikawa Nagasato A, Moro K, Bamba T, Okada M. NFκB dynamics-dependent epigenetic changes modulate inflammatory gene expression and induce cellular senescence. FEBS J 2024

Tachi T, Kijima N, Kuroda H, Ikeda S, Murakami K, Nakagawa T, Yaga M, Nakagawa K, Utsugi R, Hirayama R, Okita Y, Kagawa N, Kishima H, Imai C, Hosen N. Antitumor effects of intracranial injection of B7-H3-targeted Car-T and Car-Nk cells in a patient-derived glioblastoma xenograft model. Cancer Immunol Immunother 2024

Takaoka M, Zhao X, Lim HY, Magnussen CG, Ang O, Suffee N, Schrank PR, Ong WS, Tsiantoulas D, Sommer F, Mohanta SK, Harrison J, Meng Y, Laurans L, Wu F, Lu Y, Masters L, Newland SA, Denti L, Hong M, Chajadine M, Juonala M, Koskinen JS, Kähönen M, Pahkala K, Rovio SP, Mykkänen J, Thomson R, Kaisho T, Habenicht AJR, Clement M, Tedgui A, Ait-Oufella H, Zhao TX, Nus M, Ruhrberg C, Taleb S, Williams JW, Raitakari OT, Angeli V, Mallat Z. Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis. Nature 2024

Takasaki R, Ito E, Nagae M, Takahashi Y, Matsuoka T, Yasue W, Arichi N, Ohno H, Yamasaki S, Inuki S. Development of Ribityllumazine Analogue as Mucosal-Associated Invariant T Cell Ligands. J Am Chem Soc 2024

Tomiyasu N, Takahashi M, Toyonaga K, Yamasaki S, Bamba T, Izumi Y. Efficient lipidomic approach for the discovery of lipid ligands for immune receptors by combining LC-HRMS/MS analysis with fractionation and reporter cell assay. Anal Bioanal Chem 2024

Torta F, Hoffmann N, Burla B, Alecu I, Arita M, Bamba T, Bennett SAL, Bertrand-Michel J, Brügger B, Cala MP, Camacho-Muñoz D, Checa A, Chen M, Chocholoušková M, Cinel M, Chu-Van E, Colsch B, Coman C, Connell L, Sousa BC, Dickens AM, Fedorova M, Eiríksson FF, Gallart-Ayala H, Ghorasaini M, Giera M, Guan XL, Haid M, Hankemeier T, Harms A, Höring M, Holčapek M, Hornemann T, Hu C, Hülsmeier AJ, Huynh K, Jones CM, Ivanisevic J, Izumi Y, Köfeler HC, Lam SM, Lange M, Lee JC, Liebisch G, Lippa K, Lopez-Clavijo AF, Manzi M, Martinefski MR, Math RGH, Mayor S, Meikle PJ, Monge ME, Moon MH, Muralidharan S, Nicolaou A, Nguyen-Tran T, O’Donnell VB, Orešič M, Ramanathan A, Riols F, Saigusa D, Schock TB, Schwartz-Zimmermann H, Shui G, Singh M, Takahashi M, Thorsteinsdóttir M, Tomiyasu N, Tournadre A, Tsugawa H, Tyrrell VJ, van der Gugten G, Wakelam MO, Wheelock CE, Wolrab D, Xu G, Xu T, Bowden JA, Ekroos K, Ahrends R, Wenk MR. Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards. Nat Commun 2024

Wakamatsu E, Machiyama H, Toyota H, Takeuchi A, Hashimoto R, Kozono H, Yokosuka T. Indirect suppression of CD4 T cell activation through LAG-3-mediated trans-endocytosis of MHC class II. Cell Rep 2024

Wang M, Chen H, Zhang T, Zhang Z, Xiang X, Gao M, Guo Y, Jiang S, Yin K, Chen M, Huang J, Zhong X, Ohto U, Li J, Shimizu T, Yin H. Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus. Acta Pharm Sin B 2024

Wibowo T, Kogue Y, Ikeda S, Yaga M, Tachikawa M, Suga M, Kida S, Shibata K, Tsutsumi K, Murakami H, Ueda Y, Kato H, Fukushima K, Fujita J, Ueda T, Kusakabe S, Hino A, Ichii M, Imai C, Okuzaki D, Kumanogoh A, Hosen N. CAR-NK cells derived from cord blood originate mainly from CD56. Mol Ther Methods Clin Dev 2024

Yamaguchi M, Nakao S, Arima M, Little K, Singh A, Wada I, Kaizu Y, Zandi S, Garweg JG, Matoba T, Shiraishi W, Yamasaki R, Shibata K, Go Y, Ishibashi T, Uemura A, Stitt AW, Sonoda KH. Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation. Diabetologia 2024

Yanagi T, Kikuchi H, Takeuchi K, Susa K, Mori T, Chiga M, Yamamoto K, Furukawa A, Kanazawa T, Kato Y, Takahashi N, Suzuki T, Mori Y, Carter BC, Mori M, Nakano Y, Fujiki T, Hara Y, Suzuki S, Ando F, Mandai S, Honda S, Torii S, Shimizu S, Tanaka H, Fujii Y, Rai T, Uchida S, Sohara E. ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease. Kidney Int 2024

Zaimoku Y, Sakai K, Tsuji N, Hosomichi K, Yamada S, Tran DC, Kobayashi M, Sugiyama A, Hirayasu K, Mizumaki H, Ishiyama K, Hanayama R, Tomiyama Y, Nakao S. Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. Br J Haematol 2024

Muro R, Nitta T, Nitta S, Tsukasaki M, Asano T, Nakano K, Okamura T, Nakashima T, Okamoto K, Takayanagi H. Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity. J Clin Invest 2024

Ota A, Iguchi T, Nitta S, Muro R, Mino N, Tsukasaki M, Penninger JM, Nitta T, Takayanagi H. Synchronized development of thymic eosinophils and thymocytes. Int Immunol 2024

Li Y, Hirayasu K, Hasegawa G, Tomita Y, Hashikawa Y, Hiwa R, Arase H, Hanayama R. Fibrinogen induces inflammatory responses via the immune activating receptor LILRA2. Front Immunol 2024

Hirano Y, Ohto U, Ichi I, Sato R, Miyake K, Shimizu T. Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity. Commun Biol 2024

Setoguchi R, Sengiku T, Kono H, Kawakami E, Kubo M, Yamamoto T, Hori S. Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice. Nat Commun 2024

Ito E, Yamasaki S. Regulation of MAIT cells through host-derived antigens. Front Immunol 2024

Pavillon N, Lim EL, Tanaka A, Hori S, Sakaguchi S, Smith NI. Non-invasive detection of regulatory T cells with Raman spectroscopy. Sci Rep 2024

Nie H, Saini P, Miyamoto T, Liao L, Zielinski RJ, Liu H, Zhou W, Wang C, Murphy B, Towers M, Yang T, Qi Y, Kannan T, Kossenkov A, Tateno H, Claiborne DT, Zhang N, Abdel-Mohsen M, Zhang R. Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade. Nat Commun 2024

Kajimura Y, Taguchi A, Nagao Y, Yamamoto K, Masuda K, Shibata K, Asaoka Y, Furutani-Seiki M, Tanizawa Y, Ohta Y. E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis. Commun Biol 2024

Iwai N, Akaki K, Hia F, Li W, Yoshinaga M, Mino T, Takeuchi O. UPF1 plays critical roles in early B cell development. Nat Commun 2024

Nagai H, Adachi Y, Nakasugi T, Takigawa E, Ui J, Makino T, Miura M, Nakajima YI. Highly regenerative species-specific genes improve age-associated features in the adult Drosophila midgut. BMC Biol 2024

Nakai R, Yokota T, Tokunaga M, Takaishi M, Yokomizo T, Sudo T, Shi H, Yasumizu Y, Okuzaki D, Kokubu C, Tanaka S, Takaoka K, Yamanishi A, Yoshida J, Watanabe H, Kondoh G, Horie K, Hosen N, Sano S, Takeda J. A newly identified gene Ahed plays essential roles in murine haematopoiesis. Nat Commun 2024

Yaga M, Hasegawa K, Ikeda S, Matsubara M, Hiroshima T, Kimura T, Shirai Y, Tansri W, Uehara H, Tachikawa M, Okairi Y, Sone M, Mori H, Kogue Y, Akamine H, Okuzaki D, Kawagishi K, Kawanaka S, Yamato H, Takeuchi Y, Okura E, Kanzaki R, Okami J, Nakamichi I, Nakane S, Kobayashi A, Iwazawa T, Tokunaga T, Yokouchi H, Yano Y, Uchida J, Mori M, Komuta K, Tachi T, Kuroda H, Kijima N, Kishima H, Ichii M, Futami S, Naito Y, Shiroyama T, Miyake K, Koyama S, Hirata H, Takeda Y, Funaki S, Shintani Y, Kumanogoh A, Hosen N. CD98 heavy chain protein is overexpressed in non-small cell lung cancer and is a potential target for CAR T-cell therapy. Sci Rep 2024

Watanabe M, Matsui A, Awata N, Nagafuchi A, Kawazoe M, Harada Y, Ito M. Differences in the characteristics and functions of brain and spinal cord regulatory T cells. J Neuroinflammation 2024

Zhang Z, Aoki H, Umezawa K, Kranrod J, Miyazaki N, Oshima T, Hirao T, Miura Y, Seubert J, Ito K, Aoki S. Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells. Cell Death Discov 2024

Iwata A, Maruyama J, Natsuki S, Nishiyama A, Tamura T, Tanaka M, Shichino S, Seki T, Komai T, Okamura T, Fujio K, Asano K. Egr2 drives the differentiation of Ly6C. Commun Biol 2024

Shimizu T. RNA recognition in toll-like receptor signaling. Curr Opin Struct Biol 2024

Ding Z, Diny NL, Gentek R, Gur-Cohen S, Kimura MY, Koay HF, Magri G, Perez-Lopez A, Pikor NB, Rodda LB. Women in STEM becoming independent: Embrace failures as part of the journey to success. J Exp Med 2024

Hashimoto Y, Kawade H, Bao W, Morii S, Nakano M, Nagae M, Murakami R, Tokoro Y, Nakashima M, Cai Z, Isaji T, Gu J, Nakajima K, Kizuka Y. The K346T mutant of GnT-III bearing weak in vitro and potent intracellular activity. BBA Gen Subj 2024.

Nakano Y, Yokomoto-Umakoshi M, Nakatani K, Umakoshi H, Nakao H, Fujita M, Kaneko H, Iwahashi N, Ogasawara T, Fukumoto T, Matsuda Y, Sakamoto R, Izumi Y, Bamba T, Ogawa Y. Plasma Steroid Profiling Between Patients With and Without Diabetes Mellitus in Nonfunctioning Adrenal Incidentalomas. J Endocr Soc 2024

Arichi N, Amano T, Wu S, Inuki S, Ohno H. Synthesis of Sulfilimines via Visible-Light-Mediated Triplet Energy Transfer to Sulfonyl Azides. Chemistry 2024

Nakagawara K, Ando M, Srirat T, Mise-Omata S, Hayakawa T, Ito M, Fukunaga K, Yoshimura A. NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors. J Immunother Cancer 2024

Páez-Watson T, Tomás-Martínez S, de Wit R, Keisham S, Tateno H, van Loosdrecht MCM, Lin Y. Sweet Secrets: Exploring Novel Glycans and Glycoconjugates in the Extracellular Polymeric Substances of "Candidatus Accumulibacter”. ACS ES T Water 2024

Arai J, Hayakawa Y, Tateno H, Murakami K, Hayashi T, Hata M, Matsushita Y, Kinoshita H, Abe S, Kurokawa K, Oya Y, Tsuboi M, Ihara S, Niikura R, Suzuki N, Iwata Y, Shiokawa T, Shiomi C, Uekura C, Yamamoto K, Fujiwara H, Kawamura S, Nakagawa H, Mizuno S, Kudo T, Takahashi S, Ushiku T, Hirata Y, Fujii C, Nakayama J, Shibata S, Woods S, Worthley DL, Hatakeyama M, Wang TC, Fujishiro M. Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target. Gastroenterology 2024

Yamasaki K, Tsuzuki S, Tateno H. Stabilization of the Protein Structure by the Many-Body Cooperative Effect in the NH/π Hydrogen-bonding Tryptophan Triad. J Phys Chem B 2024

Kinashi Y, Tanaka, K, Kimura S, Hirota M, Komiyama S, Shindo T, Hashiguchi A, Takahashi D, Shibata S, Karaki SI, Ohno H, Hase K. Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice. EBioMedicine 2024

Hayabuchi H, Tokifuji Y, Takahashi H, Amagai M, Yoshimura A, Chikuma S. Disruption of post-thymic tolerance in skin-reactive TCR transgenic mice through the interaction of lymphopenia and intestinal microbiota. Int Immunol 2024

Tani-Ichi S, Obwegs D, Yoshikawa A, Watanabe H, Kitano S, Ejima A, Hatano S, Miyachi H, Cui G, Shimba A, Abe S, Hori S, Kondoh G, Sagar, Yoshikai Y, Ikuta K. A RORE-dependent Intronic Enhancer in the IL-7 Receptor-α Locus Controls Glucose Metabolism via Vγ4+ γδT17 Cells. J Immunol 2024

Inuki S, Miyamoto J, Hashimoto N, Shimizu H, Tabuchi H, Kawai A, Greiner LC, Kimura I, Ohno H. Structure-activity relationship studies of tetrahydroquinolone derivatives as GPR41 modulators. Bioorg Med Chem Lett 2024

Hollwedel FD, Maus R, Stolper J, Iwai S, Kasai H, Holtfreter S, Pich A, Neubert L, Welte T, Yamasaki S, Maus UA. Ectopic Expression of C-Type Lectin Mincle Renders Mice Susceptible to Staphylococcal Pneumonia. J Infect Dis 2024

Tokoro Y, Nagae M, Nakano M, Harduin-Lepers A, Kizuka Y. LacdiNAc synthase B4GALNT3 has a unique PA14 domain and suppresses N-glycan capping. J Biol Chem 2024

Iizuka-Koga M, Ito M, Yumoto N, Mise-Omata S, Hayakawa T, Komai K, Chikuma S, Takahashi S, Matsumoto I, Sumida T, Yoshimura A. Reconstruction of Sjögren’s syndrome-like sialadenitis by a defined disease specific gut-reactive single TCR and an autoantibody. Clin Immunol 2024

Shimazu Y, Kanda J, Onda Y, Fuchida SI, Ohta K, Shimura Y, Kosugi S, Yamamura R, Matsuda M, Hanamoto H, Adachi Y, Anzai N, Hotta M, Fukushima K, Yagi H, Yoshihara S, Tanaka Y, Takakuwa T, Tanaka H, Shibayama H, Uoshima N, Hosen N, Ito T, Shimazaki C, Matsumura I, Kuroda J, Takaori-Kondo A, Hino M. The lymphocyte/monocyte ratio predicts the efficacy of isatuximab plus pomalidomide in multiple myeloma patients. Cancer Immunol Immunother 2024

Tanaka S, Etori K, Hattori K, Tamura J, Ikeda K, Kageyama T, Meguro K, Iwamoto T, Iwata A, Furuta S, Suto A, Suzuki K, Nakajima H. CCR4 predicts the efficacy of abatacept in rheumatoid arthritis patients through the estimation of Th17 and Treg cell abundance. Mod Rheumatol 2024

Nakamichi R, Asahara H. The role of mechanotransduction in tendon. J Bone Miner Res 2024

Iwamoto N, Kai T, Inuki S, Ohno H, Maeda H, Watanabe H, Maruyama T, Oishi S. Mirror-Image Human Serum Albumin Domain III as a Tool for Analyzing Site II-Dependent Molecular Recognition. Bioconjug Chem 2024

Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H. PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. Nat Metab 2024

Iwahashi N, Umakoshi H, Fujita M, Fukumoto T, Ogasawara T, Yokomoto-Umakoshi M, Kaneko H, Nakao H, Kawamura N, Uchida N, Matsuda Y, Sakamoto R, Seki M, Suzuki Y, Nakatani K, Izumi Y, Bamba T, Oda Y, Ogawa Y. Single-cell and spatial transcriptomics analysis of human adrenal aging. Mol Metab 2024

Wang Z, Yang Z, Shishido M, Daoudi K, Hidaka M, Tateno H, Futai E, Ogawa T. Cyanobacteria Lectin (MVL) Interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein-Protein Interaction. Int J Mol Sci 2024

Aoki S. Elucidating the Mechanisms Underlying Interindividual Differences in the Onset of Adverse Drug Reactions. Biol Pharm Bull 2024

Miyahara A, Umeki A, Sato K, Nomura T, Yamamoto H, Miyasaka T, Tanno D, Matsumoto I, Zong T, Kagesawa T, Oniyama A, Kawamura K, Yuan X, Yokoyama R, Kitai Y, Kanno E, Tanno H, Hara H, Yamasaki S, Saijo S, Iwakura Y, Ishii K, Kawakami K. Innate phase production of IFN-γ by memory and effector T cells expressing early activation marker CD69 during infection with. Infect Immun 2024

Aoki K, Higashi K, Oda S, Manabe A, Maeda K, Morise J, Oka S, Inuki S, Ohno H, Oishi S, Nonaka M. Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor. ACS Chem Biol 2024

Lu X, Hayashi H, Ishikawa E, Takeuchi Y, Dychiao JVT, Nakagami H, Yamasaki S. Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies. eLife 2024

Xu Z, Notomi S, Wu G, Fukuda Y, Maehara Y, Fukushima M, Murakami Y, Takahashi M, Izumi Y, Sonoda KH. Altered fatty acid distribution in lysosome-associated membrane protein-2 deficient mice. BB Reports 2024

Dangerfield EM, Ishizuka S, Kodar K, Yamasaki S, Timmer MSM, Stocker BL. Chimeric NOD2 Mincle Agonists as Vaccine Adjuvants. J Med Chem 2024

Reis E Sousa C, Yamasaki S, Brown GD. Myeloid C-type lectin receptors in innate immune recognition. Immunity 2024

Hasegawa T, Noguchi S, Nakashima M, Miyai M, Goto M, Matsumoto Y, Torii S, Honda S, Shimizu S. Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes. J Biol Chem 2024

Aoki A, Iwamura C, Kiuchi M, Tsuji K, Sasaki A, Hishiya T, Hirasawa R, Kokubo K, Kuriyama S, Onodera A, Shimada T, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Nakamura S, Urushibara T, Kaneda S, Sakao S, Nishida O, Takahashi K, Kimura MY, Motohashi S, Igari H, Ikehara Y, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Kikuchi T, Nakayama T, Yokote K, Hirahara K. Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients. J Clin Immunol 2024

Kazaoka A, Fujimori S, Yamada Y, Shirayanagi T, Gao Y, Kuwahara S, Sakamoto N, Susukida T, Aoki S, Ito, K. HLA-B*57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir. PNAS Nexus 2024

Yoshinaga M, Takeuchi O. Regulation of inflammatory diseases via the control of mRNA decay. Inflamm Regen 2024

English K, Kwan R, Holz LE, McGuffog C, Krol JMM, Kempe D, Kaisho T, Heath WR, Lisowski L, Biro M, McCaughan GW, Bowen DG, Bertolino P. A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs. Nat Commun 2024

Mori S, Nagae M, Yamasaki S. Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands. Int Immunol 2024

Satou M, Wang J, Nakano-Tateno T, Teramachi M,Aoki S, Sugimoto H, Chik C, Tateno T. Autophagy inhibition suppresseshormone production and cell growth in pituitary tumor cells: A potential approach to pituitary tumors. Mol Cell Endocrinol 2024

Higashiyama M, Haniuda K, Nihei Y, Kazuno S, Kikkawa M, Miura Y, Suzuki Y, Kitamura D. Oral bacteria induce IgAautoantibodies against a mesangial protein in IgA nephropathy model mice. Life Sci Alliance 2024

Kurashige R, Kurashige M, Okada Y, Higuchi K, Yuda S, Hino A, Miyamura T, Ichii M, Fukushima K, Honma K, Takeuchi M, Yokota T, Ishikawa J, Sawada A, Shibayama H, Hosen N, Morii E. Differentiating between Epstein-Barr Virus-positive Lymphoid Neoplasm Relapse and Post-transplant Lymphoproliferative Disorder after Sex-mismatched Hematopoietic Stem Cell Transplantation. Am J Surg Pathol 2024

Tomida S, Nagae M, Kizuka Y. Distinctive domains and activity regulation of core fucosylation enzyme FUT8. BBA Gen Subjects 2024

Hiranuma R, Sato R, Yamaguchi K, Nakamizo S,Asano K, Shibata T, Fukui R, Furukawa Y, Kabashima K,Miyake K. Aberrant monocytopoiesis drives granuloma development in sarcoidosis. Int Immunol 2024

Srirat T, Hayakawa T, Mise-Omata S, Nakagawara K, Ando M, Shichino S,Ito M, Yoshimura A. NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment. Cell Rep 2024

Bai Y, Morita K, Kokaji T, Hatano A, Ohno S, Egami R, Pan Y, Li D, Yugi K, Uematsu S, Inoue H, Inaba Y, Suzuki Y, Matsumoto M, Takahashi M,Izumi Y, Bamba T, Hirayama A, Soga T, Kuroda S. Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity. iScience 2024

Asami J, Park JH, Nomura Y, Kobayashi C, Mifune J, Ishimoto N, Uemura T, Liu K, Sato Y, Zhang Z, Muramatsu M, Wakita T, Drew D, Iwata S, Shimizu T, Watashi K, Park SY, Nomura N, Ohto U. Structural basis of hepatitis B virus receptor binding. Nat Struct Mol Biol 2024

Hikawa N, Kashio S, Miura M. Mating-induced increase of kynurenine in Drosophila ovary enhances starvation resistance of progeny. J Biol Chem 2024

Kanno T, Miyako K, Endo T, Yokoyama S, Asou HK, Yamada K, Ohara O, Nakayama T, Kimura MY, Endo Y. ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development. Int Immunol 2024

Yagasaki L, Chiba T, Kurimoto R, Nakajima M, Iwata T, Asahara H. The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum. Regenerative Therapy 2024

Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, Akeda Y, Ohteki T, Kubo M, Yoshida K, Kawakami K, Oishi K, Araya J, Kuwano K, Kronenberg M, Endo Y, Kinjo Y. IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria. Proc Natl Acad Sci U S A 2024

Yamaguchi A, Obiya N, Arichi N, Oishi S, Ohno H, Inuki S. Synthesis of labionin and avionin precursors via a nitrogen-centred-radical-triggered 1,5-HAT reaction of Tris derivatives. Organic and Biomolecular Chemistry 2024

Aoki K, Tsuda S, Ogata N, Kataoka M, Sasaki J, Inuki S, Ohno H, Watashi K, Yoshiya T, Oishi S. Synthesis of the full-length hepatitis B virus core protein and its capsid formation. Organic and Biomolecular Chemistry 2024

Kumar SRP, Biswas M, Cao D, Arisa S, Muñoz-Melero M, Lam AK, Piñeros AR, Kapur R, Kaisho T, Kaufman RJ, Xiao W, Shayakhmetov DM, Terhorst C, de Jong YP, Herzog RW. TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling. Mol Ther 2024

Wang D, Honda S, Shin MK, Watase K, Mizusawa H, Ishikawa K, Shimizu S. Subcellular localization and ER-mediated cytotoxic function of α1A and α1ACT in spinocerebellar ataxia type 6. Biochem Biophys Res Commun 2024

Washihira N, Murakami M, Nakamura M, Fujii S, Matsushima T, Asahara H, Kishida A, Tanabe T, Kimura T, Kobayashi M, Yamamoto M. Application of a genetically engineered macrophage cell line for evaluating cellular effects of UV/US-treated poly(ethylene terephthalate) microplastics. Colloids Surf B Biointerfaces 2024

Muraosa Y, Hino Y, Takatsuka S, Watanabe A, Sakaida E, Saijo S, Miyazaki Y, Yamasaki S,Kamei K. Fungal chitin-binding glycoprotein induces Dectin-2-mediated allergic airway inflammation synergistically with chitin. PLoS Pathog 2024

Ito E, Inuki S, Izumi Y, Takahashi M, Dambayashi Y, Ciacchi L, Awad W, Takeyama A, Shibata K, Mori S, Mak JYW, Fairlie DP, Bamba T, Ishikawa E, Nagae M, Rossjohn J, Yamasaki S. Sulfated bile acid is a host-derived ligand for MAIT cells. Sci immunol 2024

Moriyama T, Yoritate M, Kato N, Saika A, Kusuhara W, Ono S, Nagatake T, Koshino H, Kiya N, Moritsuka N, Tanabe R, Hidaka Y, Usui K, Chiba S, Kudo N, Nakahashi R, Igawa K, Matoba H, Tomooka K, Ishikawa E, Takahashi S, Kunisawa J, Yamasaki S, Hirai G. Linkage-Editing Pseudo-Glycans: A Reductive α-Fluorovinyl-C-Glycosylation Strategy to Create Glycan Analogs with Altered Biological Activities. J Am Chem Soc 2024

Torigoe T, Takahashi M, Heravizadeh O, Ikeda K, Nakatani K, Bamba T, Izumi Y. Predicting Retention Time in Unified-Hydrophilic-Interaction/Anion-Exchange Liquid Chromatography High-Resolution Tandem Mass Spectrometry (Unified-HILIC/AEX/HRMS/MS) for Comprehensive Structural Annotation of Polar Metabolome. Anal Chem 2024

Tokifuji BY, Hayabuchi H, Sasaki T, Hara-Chikuma M, Hirota K, Takahashi H, Amagai M, Yoshimura A, Chikuma S. Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition. iScience 2024

Chen LM, Keisham S, Tateno H, van Ede J, Pronk M, van Loosdrecht MCM, Lin Y. Alterations of Glycan Composition in Aerobic Granular Sludge during the Adaptation to Seawater Conditions. ACS ES and T Water 2024

Anami T, Pan C, Fujiwara Y, Komohara Y, Yano H, Saito Y, Sugimoto M, Wakita D, Motoshima T, Murakami Y, Yatsuda J, Takahashi N, Suzu S, Asano K, Tamada K, Kamba T. Dysfunction of sinus macrophages in tumor-bearing host induces resistance to immunotherapy. Cancer Sci 2024

Keisham S, Saito S, Kowashi S, Tateno H. Droplet-Based Glycan and RNA Sequencing for Profiling the Distinct Cellular Glyco-States in Single Cells. Small Methods 2024

Yada Y, Matsumoto M, Inoue T, Baba A, Higuchi R, Kawai C, Yanagisawa M, Kitamura D, Ohga S, Kurosaki T, Baba Y. STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells. J Exp Med 2024

Fukushima K, Kudo H, Oka K, Hayashi A, Onizuka M, Kusakabe S, Hino A, Takahashi M, Takeda K, Mori M, Ando K, Hosen N. Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation. Bone Marrow Transplant 2024

Miyake K, Shibata T, Fukui R, Murakami Y, Sato R, Hiranuma R. Endosomal Toll-Like Receptors as Therapeutic Targets for Autoimmune Diseases. in Adv Exp Med Biol 2024

Sasaki I, Kato T, Kanazawa N, Kaisho T. Autoinflammatory Diseases Due to Defects in Degradation or Transport of Intracellular Proteins. in Adv Exp Med Biol 2024

Torigoe S, Lowman DW, Sugiki T, Williams DL, Yamasaki S. Self-recognition through Dectin-1 exacerbates liver inflammation. Genes Cells 2024

Chang S, Torii S, Inamo J, Ishikawa K, Kochi Y, Shimizu S. Uncovering the Localization and Function of a Novel Read-Through Transcript ‘TOMM40-APOE’. Cells 2024

Kimura T, Maeda H, Hagiwara M, Hashimoto Y, Nakamura N, Nomura W, Tanabe T, Kobayashi M, Yamamoto M, Matsushima T, Asahara H, Kishida A. Evaluation of Proinflammatory Response to Polymeric Materials Using a Macrophage Cell Line Genetically Tagged with a Luminescent Peptide. Advanced Biomedical Engineering 2024

Nakatani K, Izumi Y, Umakoshi H, Yokomoto-Umakoshi M, Nakaji T, Kaneko H, Nakao H, Ogawa Y, Ikeda K, Bamba T. Wide-scope targeted analysis of bioactive lipids in human plasma by LC/MS/MS. J Lipid Res 2024

Nakamura N, Arima N, Takakuwa T, Yoshioka S, Imada K, Fukushima K, Hotta M, Fuchida SI, Kanda J, Uoshima N, Shimura Y, Tanaka H, Ohta K, Kosugi S, Yagi H, Yoshihara S, Yamamura R, Adachi Y, Hanamoto H, Shibayama H, Hosen N, Ito T, Shimazaki C, Takaori-Kondo A, Kuroda J, Matsumura I, Hino M. Efficacy of elotuzumab for multiple myeloma deteriorates after daratumumab: a multicenter retrospective study. Ann Hematol 2024

Fukui C, Yamana S, Xue Y, Shirane M, Tsutsui H, Asahara K, Yoshitomi K, Ito T, Lestari T, Hasegawa E, Yawata N, Takeda A, Sonoda KH, Shibata K. Functions of mucosal associated invariant T cells in eye diseases. Front Immunol 2024

Yoshinaga M, Takeuchi O. RNA Metabolism Governs Immune Function and Response. in Adv Exp Med Biol 2024

Yoshida T, Yokoi T, Tanaka T, Matsuzaka E, Saida Y, Nishina S, Takada S, Shimizu S, Azuma N. Modeling of Retina and Optic Nerve Ischemia–Reperfusion Injury through Hypoxia–Reoxygenation in Human Induced Pluripotent Stem Cell-Derived Retinal Ganglion Cells. Cells 2024

Nishi W, Wakamatsu E, Machiyama H, Matsushima R, Yoshida Y, Nishikawa T, Toyota H, Furuhata M, Nishijima H, Takeuchi A, Suzuki M, Yokosuka T. Molecular Imaging of PD-1 Unveils Unknown Characteristics of PD-1 Itself by Visualizing “PD-1 Microclusters”. in Adv Exp Med Biol 2024

Komatsuya K, Ishikawa M, Kikuchi N, Hirabayashi T, Taguchi R, Yamamoto N, Arai M, Kasahara K. Integrin-Dependent Transient Density Increase in Detergent-Resistant Membrane Rafts in Platelets Activated by Thrombin. Biomedicines 2024

Ikeda K, Takahashi M, Bamba T, Izumi Y. Comparison of Amine-Modified Polymeric Stationary Phases for Polar Metabolomic Analysis Based on Unified-Hydrophilic Interaction/Anion Exchange Liquid Chromatography/High-Resolution Mass Spectrometry (Unified-HILIC/AEX/HRMS). Mass Spectrometry 2024

Kurihara S, Suzuki K, Yokota M, Ito T, Hayashi Y, Kikuchi R, Kageyama T, Meguro K, Tanaka S, Iwata A, Goto Y, Suto A, Nakajima H. Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells. Biomolecules 2024

Kazaoka A, Kumagai K, Matsushita J, Aida T, Kuwahara S, Aoki S, Ito K. Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption. Toxicological Research 2024

Kosakamoto H, Miura M, Obata F. Epidermal tyrosine catabolism is crucial for metabolic homeostasis and survival against high-protein diets in Drosophila. Development (Cambridge) 2024

Sasaki I, Fukuda-Ohta Y, Nakai C, Wakaki-Nishiyama N, Okamoto C, Okuzaki D, Morita S, Kaji S, Furuta Y, Hemmi H, Kato T, Yamamoto A, Tosuji E, Saitoh SI, Tanaka T, Hoshino K, Fukuda S, Miyake K, Kuroda E, Ishii KJ, Iwawaki T, Furukawa K, Kaisho T. A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages. Cell Rep 2024

Oya M, Miyasaka Y, Nakamura Y, Tanaka M, Suganami T, Mashimo T, Nakamura K. Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia. Cell Metab 2024

Iwamoto N, Sasaki J, Ohno S, Aoki K, Usui Y, Inuki S, Ohno H, Oishi S. Synthetic studies on the extracellular domain of the T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) using Trt-K10 solubilizing tags. Bioorg Med Chem 2024

Hosen N. Identification of cancer-specific cell surface targets for CAR-T cell therapy. Inflamm Regen 2024

■ 2023

Hashimoto N, Taguchi J, Arichi N, Inuki S, Ohno H. Gold(I)-Catalyzed Cascade Cyclization of Alkynyl Indoles for the Stereoselective Construction of the Quaternary Carbon Center of Akuammiline Alkaloids. J Org Chem 2023

Kawai A, Tokunoh N, Kawahara E, Tamiya S, Okamura S, Ono C, Anindita J, Tanaka H, Akita H, Yamasaki S, Kunisawa J, Okamoto T, Matsuura Y, Hirai T, Yoshioka Y. Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses. J Clin Invest 2023

Asano K, Kikuchi K, Takehara M, Ogasawara M, Yoshioka Y, Ohnishi K, Iwata A, Shimizu S, Tanaka M. Identification of small compounds that inhibit multiple myeloma proliferation by targeting c-Maf transcriptional activity. Biochem Biophys Res Commun 2023

Kaneko R, Matsui A, Watanabe M, Harada Y, Kanamori M, Awata N, Kawazoe M, Takao T, Kobayashi Y, Kikutake C, Suyama M, Saito T, Saido TC, Ito M. Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease. Inflamm Regen 2023

Echizen H, Hanaoka K, Shimamoto K, Hibi R, Toma-Fukai S, Ohno H, Sasaki E, Komatsu T, Ueno T, Tsuchiya Y, Watanabe Y, Otsuka T, Saito H, Nagatoishi S, Tsumoto K, Kojima H, Okabe T, Shimizu T, Urano Y. Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation. Sci Rep 2023

Shimazu Y, Kanda J, Kosugi S, Ito T, Kaneko H, Imada K, Shimura Y, Fuchida SI, Fukushima K, Tanaka H, Yoshihara S, Ohta K, Uoshima N, Yagi H, Shibayama H, Yamamura R, Tanaka Y, Uchiyama H, Onda Y, Adachi Y, Hanamoto H, Takahashi R, Matsuda M, Miyoshi T, Takakuwa T, Hino M, Hosen N, Nomura S, Shimazaki C, Matsumura I, Takaori-Kondo A, Kuroda J. Efficacy of elotuzumab for multiple myeloma in reference to lymphocyte counts and kappa/lambda ratio or B2 microglobulin. Sci Rep 2023

Yan M, Tsukasaki M, Muro R, Ando Y, Nakamura K, Komatsu N, Nitta T, Okamura T, Okamoto K, Takayanagi H. Identification of an intronic enhancer regulating RANKL expression in osteocytic cells. Bone Research 2023

Liu G, Haw TJ, Starkey MR, Philp AM, Pavlidis S, Nalkurthi C, Nair PM, Gomez HM, Hanish I, Hsu AC, Hortle E, Pickles S, Rojas-Quintero J, Estepar RSJ, Marshall JE, Kim RY, Collison AM, Mattes J, Idrees S, Faiz A, Hansbro NG, Fukui R, Murakami Y, Cheng HS, Tan NS, Chotirmall SH, Horvat JC, Foster PS, Oliver BG, Polverino F, Ieni A, Monaco F, Caramori G, Sohal SS, Bracke KR, Wark PA, Adcock IM, Miyake K, Sin DD, Hansbro PM. TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase. Nat Commun 2023

Soma Y, Tominaga S, Tokito K, Imado Y, Naka K, Hanai T, Takahashi M, Izumi Y, Bamba T. Trace impurities in sodium phosphate influences the physiological activity of Escherichia coli in M9 minimal medium. Sci Rep 2023

Mehanna S, Arakawa S, Imasaka M, Chen W, Nakanishi Y, Nishiura H, Shimizu S, Ohmuraya M. Beclin1 is essential for the pancreas development. Dev Biol 2023

Kosakamoto H, Obata F, Kuraishi J, Aikawa H, Okada R, Johnstone JN, Onuma T, Piper MDW, Miura M. Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila. Nat Commun 2023

Nakamura S, Miyachi Y, Shinjo A, Yokomizo H, Takahashi M, Nakatani K, Izumi Y, Otsuka H, Sato N, Sakamoto R, Miyazawa T, Bamba T, Ogawa Y. Improved endurance capacity of diabetic mice during SGLT2 inhibition: Role of AICARP, an AMPK activator in the soleus. Journal of Cachexia, Sarcopenia and Muscle 2023

Shiratori H, Oguchi H, Isobe Y, Han KH, Sen A, Yakebe K, Takahashi D, Fukushima M, Arita M, Hase K. Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation. Sci Rep 2023

Sakurai HT, Arakawa S, Yamaguchi H, Torii S, Honda S, Shimizu S. An Overview of Golgi Membrane-Associated Degradation (GOMED) and Its Detection Methods. Cells 2023

Yoshinaga M. The crossroads of RNA methylation and ferroptosis: Implications for disease pathogenesis. Clinical and Translational Discovery 2023

Nishimoto K, Okahashi N, Maruyama M, Izumi Y, Nakatani K, Ito Y, Iida J, Bamba T, Matsuda F. Lipidome and metabolome analyses reveal metabolic alterations associated with MCF-7 apoptosis upon 4-hydroxytamoxifen treatment. Sci Rep 2023

Ochiai T, Inukai T, Akiyama M, Furui K, Ohue M, Matsumori N, Inuki S, Uesugi M, Sunazuka T, Kikuchi K, Kakeya H, Sakakibara Y. Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity. Commun Chem 2023

Fujita S, Takahashi M, Kumano G, Kuranaga E, Miura M, Nakajima YI. Distinct stem-like cell populations facilitate functional regeneration of the Cladonema medusa tentacle. PLoS Biol 2023

Miyamura S, Oe R, Nakahara T, Koresawa H, Okada S, Taue S, Tokizane Y, Minamikawa T, Yano TA, Otsuka K, Sakane A, Sasaki T, Yasutomo K, Kajisa T, Yasui T. Rapid, high-sensitivity detection of biomolecules using dual-comb biosensing. Sci Rep 2023

Osuka RF, Nagae M, Ohuchi A, Ohno S, Yamaguchi Y, Kizuka Y. The cancer-associated glycosyltransferase GnT-V (MGAT5) recognizes the N-glycan core via residues outside its catalytic pocket. FEBS Lett 2023

Li S, Toriumi H, Takahashi D, Kamasaki T, Fujioka Y, Nagatoishi S, Li J, Liu Y, Hosokawa T, Tsumoto K, Ohba Y, Katayama Y, Murakami D, Hase K, Mori T. Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles. Biomaterials 2023

Aoki K, Manabe A, Kimura H, Katoh Y, Inuki S, Ohno H, Nonaka M, Oishi S. Mirror-Image Single-Domain Antibody for a Novel Nonimmunogenic Drug Scaffold. Bioconjug Chem 2023

Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, Sakamoto DM, Kojima Y, Nishida M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y, Yanai H, Takano H, Yao R, Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, Osawa T. Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth. EMBO J 2023

Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, Wang K, Hirose H, Sasahara A, Yano M, Ishikawa S, Inokuchi M, Ota T, Tanabe M, Tada KI, Akiyama T, Cheng X, Liu CC, Yamashita T, Sugano S, Uchida Y, Chiba T, Asahara H, Nakagawa M, Sato S, Miyagi Y, Shimamura T, Nagai LAE, Kanai A, Katoh M, Nomura S, Nakato R, Suzuki Y, Tojo A, Voon DC, Ogawa S, Okamoto K, Foukakis T, Gotoh N. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. J Clin Invest 2023

Iwamoto N, Sato Y, Manabe A, Inuki S, Ohno H, Nonaka M, Oishi S. Design and Synthesis of Monobody Variants with Low Immunogenicity. ACS Med Chem Lett 2023

Joachim A, Aussel R, Gélard L, Zhang F, Mori D, Grégoire C, Merino SV, Gaya M, Liang Y, Malissen M, Malissen B. Defective LAT signalosome pathology in mice mimics human IgG4-related disease at single-cell level. J Exp Med 2023

Kawahara R, Usami T, Arakawa S, Kamo H, Suzuki T, Komatsu R, Hara H, Niwa Y, Shimizu E, Dohmae N, Shimizu S, Simizu S. Biogenesis of fibrils requires C-mannosylation of PMEL. FEBS J 2023

Sugimura M, Seike T, Okahashi N, Izumi Y, Bamba T, Ishii J, Matsuda F. Improved 2,3-Butanediol Production Rate of Metabolically Engineered Saccharomyces cerevisiae by Deletion of RIM15 and Activation of Pyruvate Consumption Pathway. Int J Mol Sci 2023

Ishizaka ST, Hawkins L, Chen Q, Tago F, Yagi T, Sakaniwa K, Zhang Z, Shimizu T, Shirato M. A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus. Eur J Pharmacol 2023

Suzuki R, Mattos DR, Kitamura T, Tsujioka R, Kobayashi K, Inuki S, Ohno H, Ishmael JE, McPhail KL, Oishi S. Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A. ACS Med Chem Lett 2023

Zhang Z, Shibata T, Fujimura A, Kitaura J, Miyake K, Ohto U, Shimizu T. Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature 2023

Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, Sugaya M, Hibino S, Nishida M, Hasegawa M, Morita H, Ando R, Tsuchida R, Yoshida M, Kodama T, Yanai H, Shimamura T, Osawa T. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus 2023

Nagai H, Nagai LAE, Tasaki S, Nakato R, Umetsu D, Kuranaga E, Miura M, Nakajima Y. Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growth in Drosophila. Dev Cell 2023

Kashio S, Masuda S, Miura M. Involvement of neuronal tachykinin-like receptor at 86C in Drosophila disc repair via regulation of kynurenine metabolism. iScience 2023

Matsuoka T, Hattori A, Oishi S, Araki M, Ma B, Fujii T, Arichi N, Okuno Y, Kakeya H, Yamasaki S, Ohno H, Inuki S. Establishment of an MR1 Presentation Reporter Screening System and Identification of Phenylpropanoid Derivatives as MR1 Ligands. J Med Chem 2023

Torii S, Arakawa S, Sato S, Ishikawa KI, Taniguchi D, Sakurai HT, Honda S, Hiraoka Y, Ono M, Akamatsu W, Hattori N, Shimizu S. Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2. EMBO Mol Med 2023

Furukawa A, Shuchi Y, Wang J, Guillen-Poza PA, Ishizuka S, Kagoshima M, Ikeno R, Kumeta H, Yamasaki S, Matsumaru T, Saitoh T, Maenaka K. Structural basis for plastic glycolipid recognition of the C-type lectin Mincle. Structure 2023

Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med 2023

Takeda H, Murakami S, Liu Z, Sawa T, Takahashi M, Izumi Y, Bamba T, Sato H, Akaike T, Sekine H, Motohashi H. Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop. Redox Biology 2023

Kimura A, Takagi T, Thamamongood T, Sakamoto S, Ito T, Seki I, Okamoto M, Aono H, Serada S, Naka T, Imataka H, Miyake K, Ueda T, Miyanokoshi M, Wakasugi K, Iwamoto N, Ohmagari N, Iguchi T, Nitta T, Takayanagi H, Yamashita H, Kaneko H, Tsuchiya H, Fujio K, Handa H, Suzuki H. Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4. Ann Rheum Dis 2023

Shinoda N, Horikoshi M, Taira Y, Muramoto M, Hirayama S, Murata S, Miura M. Caspase cleaves Drosophila BubR1 to modulate spindle assembly checkpoint function and lifespan of the organism. FEBS J 2023

Nakao H, Yokomoto-Umakoshi M, Nakatani K, Umakoshi H, Ogata M, Fukumoto T, Kaneko H, Iwahashi N, Fujita M, Ogasawara T, Matsuda Y, Sakamoto R, Izumi Y, Bamba T, Ogawa Y. Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism. eBioMedicine 2023

Maezawa Y, Endo Y, Kono S, Ohno T, Nakamura Y, Teramoto N, Yamaguchi A, Aono K, Minamizuka T, Kato H, Ishikawa T, Koshizaka M, Takemoto M, Nakayama T, Yokote K. Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events. Journal of Diabetes Investigation 2023

Susukida T, Sasaki SI, Shirayanagi T, Aoki S, Ito K, Hayakawa Y. Drug-induced altered self-presentation increases tumor immunogenicity. Biomed Pharmacother 2023

Kodama M, Toyokawa G, Sugahara O, Sugiyama S, Haratake N, Yamada Y, Wada R, Takamori S, Shimokawa M, Takenaka T, Tagawa T, Kittaka H, Tsuruda T, Tanaka K, Komatsu Y, Nakata K, Imado Y, Yamazaki K, Okamoto I, Oda Y, Takahashi M, Izumi Y, Bamba T, Shimizu H, Yoshizumi T, Nakayama KI. Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy. Cell Rep 2023

Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A. SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine. Cell Rep 2023

Oka S, Watanabe M, Ito E, Takeyama A, Matsuoka T, Takahashi M, Izumi Y, Arichi N, Ohno H, Yamasaki S, Inuki S. Archaeal Glycerolipids Are Recognized by C-Type Lectin Receptor Mincle. J Am Chem Soc 2023

Ugur M, Labios RJ, Fenton C, Knöpper K, Jobin K, Imdahl F, Golda G, Hoh K, Grafen A, Kaisho T, Saliba AE, Grün D, Gasteiger G, Bajénoff M, Kastenmüller W. Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks. Immunity 2023

Koyama-Nasu R, Kimura MY, Kiuchi M, Aoki A, Wang Y, Mita Y, Hasegawa I, Endo Y, Onodera A, Hirahara K, Motohashi S, Nakayama T. CD69 Imposes Tumor-Specific CD8þ T-cell Fate in Tumor-Draining Lymph Nodes. Cancer Immunology Research 2023

Nihei Y, Higashiyama M, Miyauchi K, Haniuda K, Suzuki Y, Kubo M, Kitamura D. Subcutaneous immunisation with zymosan generates mucosal IgA-eliciting memory and protects mice from heterologous influenza virus infection. Int Immunol 2023

Endo Y, Kanno T, Nakajima T, Ikeda K, Taketomi Y, Yokoyama S, Sasamoto S, Asou HK, Miyako K, Hasegawa Y, Kawashima Y, Ohara O, Murakami M, Nakayama T. 1-Oleoyl-lysophosphatidylethanolamine stimulates RORγt activity in TH17 cells. Sci Immunol 2023

Kuroda Y, Oda T, Shimomura O, Louphrasitthiphol P, Mathis BJ, Tateno H, Hatano K. Novel positron emission tomography imaging targeting cell surface glycans for pancreatic cancer: 18F-labeled rBC2LCN lectin. Cancer Sci 2023

Shin J, Miyaki S, Asahara H, Akimoto T. MicroRNA-140 is not involved in sepsis-induced muscle atrophy. Am J Physiol 2023

Cui W, Nagano Y, Morita S, Tanoue T, Yamane H, Ishikawa K, Sato T, Kubo M, Hori S, Taniguchi T, Hatakeyama M, Atarashi K, Honda K. Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice. J Exp Med 2023

Narukawa Y, Sugiyama N, Miura J, Yamashita R, Tominaga S, Izumi Y, Bamba T, Ishihama Y, Kashiwagi Y, Murakami S. Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium. J Periodontal Res 2023

Sakurai HT, Iwashita H, Arakawa S, Yikelamu A, Kusaba M, Kofuji S, Nishina H, Ishiyama M, Ueno Y, Shimizu S. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience 2023

Yoshida Y, Takeuchi H, Nakagawa K, Fujii T, Arichi N, Oishi S, Ohno H, Inuki S. Construction of a Bicyclo[2.2.2]octene Skeleton via a Visible-Light-Mediated Radical Cascade Reaction of Amino Acid Derivatives with N-(2-Phenyl)benzoyl Groups. Org Lett 2023

Iida K, Suga K, Suzuki K, Kurihara S, Yabe Y, Kageyama T, Meguro K, Tanaka S, Iwata A, Suto A, Nakajima H. A role of Achaete-scute complex homolog 2 in T follicular regulatory cell development. Biochem Biophys Res Commun 2023

Onodera A, Kokubo K, Okano M, Onoue M, Kiuchi M, Iwamura C, Iinuma T, Kimura MY, Ebihara N, Hanazawa T, Nakayama T, Hirahara K. Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacol Ther 2023

Nakano S, Kashio S, Nishimura K, Takeishi A, Kosakamoto H, Obata F, Kuranaga E, Chihara T, Yamauchi Y, Isobe T, Miura M. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. PLoS Genet 2023

Nishi W, Wakamatsu E, Machiyama H, Matsushima R, Saito K, Yoshida Y, Nishikawa T, Takehara T, Toyota H, Furuhata M, Nishijima H, Takeuchi A, Azuma M, Suzuki M, Yokosuka T. Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters. Nat Commun 2023

Toma-Fukai S, Sawada Y, Maeda A, Shimizu H, Shikanai T, Takenaka M, Shimizu T. Structural insight into the activation of an Arabidopsis organellar C-to-U RNA editing enzyme by active site complementation. Plant Cell 2023

Watanabe-Yasuoka Y, Gotou A, Shimizu S, Sashihara T. Lactiplantibacillus plantarum OLL2712 Induces Autophagy via MYD88 and Strengthens Tight Junction Integrity to Promote the Barrier Function in Intestinal Epithelial Cells. Nutrients 2023

Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI. FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation.Cell Rep 2023

Nakamichi R, Hishikawa A, Chikuma S, Yoshimura A, Sasaki T, Hashiguchi A, Abe T, Tokuhara T, Yoshimoto N, Nishimura ES, Hama EY, Azegami T, Nakayama T, Hayashi K, Itoh H. Erratum: DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation (Cell Reports (2023) 42(4), (S2211124723003133), (10.1016/j.celrep.2023.112302)). Cell Rep 2023

Ikazaki T, Ishikawa E, Tamashima H, Akiyama H, Kimuro Y, Yoritate M, Matoba H, Imamura A, Ishida H, Yamasaki S, Hirai G. Ligand-Controlled Stereoselective Synthesis and Biological Activity of 2-Exomethylene Pseudo-glycoconjugates: Discovery of Mincle-Selective Ligands. Angew Chem Int Ed Engl 2023

Morita R, Kubota-Koketsu R, Lu X, Sasaki T, Nakayama EE, Liu YC, Okuzaki D, Motooka D, Wing JB, Fujikawa Y, Ichida Y, Amo K, Goto T, Hara J, Shirano M, Yamasaki S, Shioda T. COVID-19 relapse associated with SARS-CoV-2 evasion from CD4+ T-cell recognition in an agammaglobulinemia patient. iScience 2023

Kato K, Haniuda K, Fukao S, Kitamura D. B cell-intrinsic DNase1L3 is essential for the T cell-independent type II response in mice. Int Immunol 2023

Ono Y, Schlesinger S, Fukunaga K, Yambe S, Sato T, Sasaki T, Shukunami C, Asahara H, Inui M. Scleraxis-lineage cells are required for correct muscle patterning. Development 2023

Chowdhury SI, Inui M, Yamazaki T, Tomono S, Takagi H, Biswas M, Saitoh SI, Miyake K, Akashi-Takamura S. The anti-TLR4 monoclonal antibody Sa15-21 enhances inflammatory cytokine production in LPS-stimulated macrophages. FEBS Lett 2023

Hino A, Fukushima K, Kusakabe S, Ueda T, Sudo T, Fujita J, Motooka D, Takeda AK, Shinozaki NO, Watanabe S, Yokota T, Shibayama H, Nakamura S, Hosen N. Prolonged gut microbial alterations in post-transplant survivors of allogeneic haematopoietic stem cell transplantation. Br J Haematol 2023

Odaka H, Tateno H. Single-Cell Glycan and RNA Sequencing (scGR-seq). Curr Protoc 2023

Kanno T, Nakajima T, Miyako K, Endo Y. Lipid metabolism in Th17 cell function. Pharmacol Ther 2023

Watanabe T, Tateno H. Lectin Blotting of Cell Lysates. Curr Protoc 2023

Nakamichi R, Hishikawa A, Chikuma S, Yoshimura A, Sasaki T, Hashiguchi A, Abe T, Tokuhara T, Yoshimoto N, Nishimura ES, Hama EY, Azegami T, Nakayama T, Hayashi K, Itoh H. DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation. Cell Rep 2023

Gokhale S, Victor E, Tsai J, Spirollari E, Matracz B, Takatsuka S, Jung J, Kitamura D, Xie P. Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4. J Immunol 2023

Onuma T, Yamauchi T, Kosakamoto H, Kadoguchi H, Kuraishi T, Murakami T, Mori H, Miura M, Obata F. Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan. PLoS Genet 2023

Morikawa T, Takahashi M, Izumi Y, Bamba T, Moriyama K, Hattori G, Fujioka R, Miura S, Shibata H. Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28. Biomedicines 2023

Inotsume M, Chiba T, Matsushima T, Kurimoto R, Nakajima M, Kato T, Shishido K, Liu L, Kawakami K, Asahara H. One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett 2023

Thathsaranie P. Manthrirathna MA, Kodar K, Ishizuka S, Dangerfield EM, Xiuyuan L, Yamasaki S, Stocker BL, S. M. Timmer M. 6-C-Linked trehalose glycolipids signal through Mincle and exhibit potent adjuvant activity. Bioorg Chem 2023

Kuroda Y, Oda T, Shimomura O, Hashimoto S, Akashi Y, Miyazaki Y, Furuya K, Furuta T, Nakahashi H, Louphrasitthiphol P, Mathis BJ, Nakajima T, Tateno H. Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer. Int J Cancer 2023

Amano S, Haniuda K, Fukao S, Aoki H, Ueha S, Kitamura D. Commensal Bacteria and the Lung Environment Are Responsible for Th2-Mediated Memory Yielding Natural IgE in MyD88-Deficient Mice.J Immunol 2023

Mawaribuchi S, Shimomura O, Oda T, Hiemori K, Shimizu K, Yamase K, Date M, Tateno H. rBC2LCN-reactive SERPINA3 is a glycobiomarker candidate for pancreatic ductal adenocarcinoma. Glycobiology 2023

Tsujioka M, Miyazawa K, Ohmuraya M, Nibe Y, Shirokawa T, Hayasaka H, Mizushima T, Fukuma T, Shimizu S. Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression. Cell Death Dis 2023

Ueda T, Fujita J, Akazawa Y, Kawamura A, Matsui T, Hino A, Kusakabe S, Sudo T, Fukushima K, Yokota T, Miyagawa S, Sakata Y, Hosen N. Successful Bridging to Allogeneic Hematopoietic Stem Cell Transplantation by Azacitidine and Venetoclax in a Case of Acute Myeloid Leukemia With t(3;3)(q21.3;q26.2) Developed Early After Orthotopic Heart Transplantation. Transplant Proc 2023

Ito Y, Uda S, Kokaji T, Hirayama A, Soga T, Suzuki Y, Kuroda S, Kubota H. Comparison of hepatic responses to glucose perturbation between healthy and obese mice based on the edge type of network structures. Sci Rep 2023

Udo T, Matsuoka Y, Takahashi M, Izumi Y, Saito K, Tazoe K, Tanaka M, Naka H, Bamba T, Yamada KI. Structural Analysis of Intracellular Lipid Radicals by LC/MS/MS Using a BODIPY-Based Profluorescent Nitroxide Probe. Anal Chem 2023

Kuchitsu Y, Mukai K, Uematsu R, Takaada Y, Shinojima A, Shindo R, Shoji T, Hamano S, Ogawa E, Sato R, Miyake K, Kato A, Kawaguchi Y, Nishitani-Isa M, Izawa K, Nishikomori R, Yasumi T, Suzuki T, Dohmae N, Uemura T, Barber GN, Arai H, Waguri S, Taguchi T. STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes. Nat Cell Biol 2023

Reynoso GV, Gordon DN, Kalia A, Aguilar CC, Malo CS, Aleshnick M, Dowd KA, Cherry CR, Shannon JP, Vrba SM, Holmes AC, Alippe Y, Maciejewski S, Asano K, Diamond MS, Pierson TC, Hickman HD. Zika virus spreads through infection of lymph node-resident macrophages. Cell Rep 2023

Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y. TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney. JCI Insight 2023

Tsuji A, Masuya T, Arichi N, Inuki S, Murai M, Miyoshi H, Ohno H. Discovery of Bis-sulfonamides as Novel Inhibitors of Mitochondrial NADH-Quinone Oxidoreductase (Complex I). ACS Med Chem Lett 2023

Jaroonwitchawan T, Arimochi H, Sasaki Y, Ishifune C, Kondo H, Otsuka K, Tsukumo SI, Yasutomo K. Stimulation of the farnesoid X receptor promotes M2 macrophage polarization. Front Immunol 2023

Liu X, Sato N, Yabushita T, Li J, Jia Y, Tamura M, Asada S, Fujino T, Fukushima T, Yonezawa T, Tanaka Y, Fukuyama T, Tsuchiya A, Shikata S, Iwamura H, Kinouchi C, Komatsu K, Yamasaki S, Shibata T, Sasaki AT, Schibler J, Wunderlich M, O′Brien E, Mizukawa B, Mulloy JC, Sugiura Y, Takizawa H, Shibata T, Miyake K, Kitamura T, Goyama S. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. EMBO Mol Med 2023

Taya N, Katakami N, Omori K, Hosoe S, Watanabe H, Takahara M, Miyashita K, Nishizawa H, Konya Y, Obara S, Hidaka A, Nakao M, Takahashi M, Izumi Y, Shimomura I, Bamba T. Change in fatty acid composition of plasma triglyceride caused by a 2 week comprehensive risk management for diabetes: A prospective observational study of type 2 diabetes patients with supercritical fluid chromatography/mass spectrometry-based semi-target lipidomic analysis. J Diabetes Investig 2023

Kaczmarek R, Piñeros AR, Patterson PE, Bertolini TB, Perrin GQ, Sherman A, Born J, Arisa S, Arvin MC, Kamocka MM, Martinez MM, Dunn KW, Quinn SM, Morris JJ, Wilhelm AR, Kaisho T, Munoz-Melero M, Biswas M, Kaplan MH, Linnemann AK, George LA, Camire RM, Herzog RW. Factor VIII trafficking to CD4+ T cells shapes its immunogenicity and requires several types of antigen-presenting cells. Blood 2023

Shibamiya A, Miyamoto-Nagai Y, Koide S, Oshima M, Rizq O, Aoyama K, Nakajima-Takagi Y, Kato R, Kayamori K, Isshiki Y, Oshima-Hasegawa N, Muto T, Tsukamoto S, Takeda Y, Koyama-Nasu R, Chiba T, Honda H, Yokote K, Iwama A, Sakaida E, Mimura N. The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms. Cancer Immunol Immunother 2023

Naito Y, Koyama S, Masuhiro K, Hirai T, Uenami T, Inoue T, Osa A, Machiyama H, Watanabe G, Sax N, Villa J, Kinugasa-Katayama Y, Nojima S, Yaga M, Hosono Y, Okuzaki D, Satoh S, Tsuda T, Nakanishi Y, Suga Y, Morita T, Fukushima K, Nishide M, Shiroyama T, Miyake K, Iwahori K, Hirata H, Nagatomo I, Yano Y, Tamiya M, Kumagai T, Takemoto N, Inohara H, Yamasaki S, Yamashita K, Aoshi T, Akbay EA, Hosen N, Shintani Y, Takamatsu H, Mori M, Takeda Y, Kumanogoh A. Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation. Sci Adv 2023

Greiner LC, Arichi N, Inuki S, Ohno H. Alkoxymigration onto α-Imino Gold Carbenes for Constructing Propellane-Type Indolines. Asian J Org Chem 2023

Kodar K, Dangerfield EM, Foster AJ, Forsythe D, Ishizuka S, McConnell MJ, Yamasaki S, Timmer MSM, Stocker BL. Aryl-functionalised α,α′-Trehalose 6,6′-Glycolipid Induces Mincle-independent Pyroptotic Cell Death. Inflammation 2023

Yoshikawa FSY, Wakatsuki M, Yoshida K, Yabe R, Torigoe S, Yamasaki S, Barber GN, Saijo S. Dectin-1/IL-15 Pathway Affords Protection against Extrapulmonary Aspergillus fumigatus Infection by Regulating Natural Killer Cell Survival. J Innate Immun 2023

Lorè NI, Yamasaki S, Simmonds RE, Jo EK. Editorial: Host-pathogen interactions in nontuberculous mycobacterial infections. Front Immunol 2023

Tsuno H, Shen J, Komatsu H, Arichi N, Inuki S, Ohno H. Gold(I)-Catalyzed Bis-Cyclization of Allenynes for the Synthesis of Strained and Planar Polycyclic Compounds. Angew Chem Int Ed Engl 2023

Morino K, Kunimura K, Sugiura Y, Izumi Y, Matsubara K, Akiyoshi S, Maeda R, Hirotani K, Sakata D, Mizuno S, Takahashi S, Bamba T, Uruno T, Fukui Y. Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury. Front Immunol 2023

Domenjo-Vila E, Casella V, Iwabuchi R, Fossum E, Pedragosa M, Castellví Q, Cebollada Rica P, Kaisho T, Terahara K, Bocharov G, Argilaguet J, Meyerhans A. XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections. Cell Rep 2023

Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara M, Yamashita M, Shichino S, Tanaka M, Asano K. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Rep 2023

Watanabe M, Motooka D, Yamasaki S. The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells. Sci Signal 2023

Bedard M, van der Niet S, Bernard EM, Babunovic GH, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB. A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages. J Clin Invest 2023

Shimizu T, Schutt CR, Izumi Y, Tomiyasu N, Omahdi Z, Kano K, Takamatsu H, Aoki J, Bamba T, Kumanogoh A, Takao M, Yamasaki S. Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease. Immunity 2023

Yamamoto H, Uchida Y, Kurimoto R, Chiba T, Matsushima T, Ito Y, Inotsume M, Miyata K, Watanabe K, Inada M, Goshima N, Uchida T, Asahara H. RNA-binding protein LIN28A upregulates transcription factor HIF1alpha by posttranscriptional regulation via direct binding to UGAU motifs. J Biol Chem 2023

Ueki K, Sueyoshi K, Inuki S, Fujimoto Y. Chemical Synthesis and Molecular Interaction Analysis of alpha-Galactosyl Ceramide Derivatives as CD1d Ligands. Methods Mol Biol 2023

Si-Hung L, Izumi Y, Bamba T. First proof-of-concept of UC/HILIC for extending the versatility of the current art of supercritical fluid separation. Anal Chim Acta 2023

Schutt CR, Yamasaki S. Lectin recruits pathogenic bugs. J Exp Med 2023

Sakaniwa K, Fujimura A, Shibata T, Shigematsu H, Ekimoto T, Yamamoto M, Ikeguchi M, Miyake K, Ohto U, Shimizu T. TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nat Commun 2023

Nishimura N, Tomiyasu N, Torigoe S, Mizuno S, Fukano H, Ishikawa E, Katano H, Hoshino Y, Matsuo K, Takahashi M, Izumi Y, Bamba T, Akashi K, Yamasaki S. Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses. Tuberculosis (Edinb) 2023

Nakajima A, Murakami R, Hori S. Functional Analysis of Foxp3 and Its Mutants by Retroviral Transduction of Murine Primary CD4+ T Cells. Methods Mol Biol 2023

Miyamoto J, Shimizu H, Hisa K, Matsuzaki C, Inuki S, Ando Y, Nishida A, Izumi A, Yamano M, Ushiroda C, Irie J, Katayama T, Ohno H, Itoh H, Yamamoto K, Kimura I. Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides. Gut Microbes 2023

Guenther C, Watanabe M, Yamasaki S. Immunomodulatory Functions of Glycolipids from Pathogens. Methods Mol Biol 2023

Greiner LC, Arichi N, Inuki S, Ohno H. Gold(I)-Catalyzed Benzylic C(sp(3) )-H Functionalizations: Divergent Synthesis of Indole[a]- and [b]-Fused Polycycles. Angew Chem Int Ed Engl 2023

Fujito Y, Izumi Y, Nakatani K, Takahashi M, Hayakawa Y, Takayama M, Bamba T. Understanding the mechanism of CO(2)-Assisted electrospray ionization for parameter optimization in supercritical fluid chromatography mass spectrometry. Anal Chim Acta 2023

■ 2022

Zhang Z, Nomura N, Muramoto Y, Ekimoto T, Uemura T, Liu K, Yui M, Kono N, Aoki J, Ikeguchi M, Noda T, Iwata S, Ohto U, Shimizu T. Structure of SARS-CoV-2 membrane protein essential for virus assembly. Nat Commun 2022

Yano TA, Kajisa T, Ono M, Miyasaka Y, Hasegawa Y, Saito A, Otsuka K, Sakane A, Sasaki T, Yasutomo K, Hamajima R, Kanai Y, Kobayashi T, Matsuura Y, Itonaga M, Yasui T. Ultrasensitive detection of SARS-CoV-2 nucleocapsid protein using large gold nanoparticle-enhanced surface plasmon resonance. Sci Rep 2022

Xiao Y, Zhang Y, Yin H, Shimizu T. Editorial: Frontiers on innate immunity and intercellular communication. Front Immunol 2022

Tsukumo SI, Subramani PG, Seija N, Tabata M, Maekawa Y, Mori Y, Ishifune C, Itoh Y, Ota M, Fujio K, Di Noia JM, Yasutomo K. AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination. Sci Adv 2022

Tomida S, Nagae M, Kizuka Y. The stem region of alpha1,6-fucosyltransferase FUT8 is required for multimer formation but not catalytic activity. J Biol Chem 2022

Teijeira A, Garasa S, Luri-Rey C, de Andrea C, Gato M, Molina C, Kaisho T, Cirella A, Azpilikueta A, Wculek SK, Egea J, Olivera I, Rodriguez I, Rouzaut A, Verkhusha V, Valencia K, Sancho D, Berraondo P, Melero I. Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy. Cancer Res 2022

Tatsuguchi T, Uruno T, Sugiura Y, Oisaki K, Takaya D, Sakata D, Izumi Y, Togo T, Hattori Y, Kunimura K, Sakurai T, Honma T, Bamba T, Nakamura M, Kanai M, Suematsu M, Fukui Y. Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity. Biochem Biophys Res Commun 2022

Tanioku T, Nishibata M, Tokinaga Y, Konno K, Watanabe M, Hemmi H, Fukuda-Ohta Y, Kaisho T, Furue H, Kawamata T. Tmem45b is essential for inflammation- and tissue injury–induced mechanical pain hypersensitivity. Proc Natl Acad Sci U S A 2022

Suzuki Y, Miyazaki T, Muto H, Kubara K, Mukai Y, Watari R, Sato S, Kondo K, Tsukumo SI, Yasutomo K, Ito M, Tsukahara K. Design and lyophilization of lipid nanoparticles for mRNA vaccine and its robust immune response in mice and nonhuman primates. Mol Ther Nucleic Acids 2022

Soma Y, Izumi Y, Shimohira T, Takahashi M, Imado Y, Tominaga S, Tokito K, Hata K, Shinadama S, Oshiro M, Hayakawa Y, Bamba T. In-Needle Pre-Column Derivatization for Amino Acid Quantification (iPDAQ) Using HPLC. Metabolites 2022

Shibata K, Shimizu T, Nakahara M, Ito E, Legoux F, Fujii S, Yamada Y, Furutani-Seiki M, Lantz O, Yamasaki S, Watarai M, Shirai M. The intracellular pathogen Francisella tularensis escapes from adaptive immunity by metabolic adaptation. Life Sci Alliance 2022

Shibata K, Motozono C, Nagae M, Shimizu T, Ishikawa E, Motooka D, Okuzaki D, Izumi Y, Takahashi M, Fujimori N, Wing JB, Hayano T, Asai Y, Bamba T, Ogawa Y, Furutani-Seiki M, Shirai M, Yamasaki S. Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. Nat Commun 2022

Sasako T, Umehara T, Soeda K, Kaneko K, Suzuki M, Kobayashi N, Okazaki Y, Tamura-Nakano M, Chiba T, Accili D, Kahn CR, Noda T, Asahara H, Yamauchi T, Kadowaki T, Ueki K. Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice. Nat Commun 2022

Raveney BJE, El-Darawish Y, Sato W, Arinuma Y, Yamaoka K, Hori S, Yamamura T, Oki S. Neuropilin-1 (NRP1) expression distinguishes self-reactive helper T cells in systemic autoimmune disease. EMBO Mol Med 2022

Osada N, Nagae M, Nakano M, Hirata T, Kizuka Y. Examination of differential glycoprotein preferences of N-acetylglucosaminyltransferase-IV isozymes a and b. J Biol Chem 2022

Nakatani K, Izumi Y, Takahashi M, Bamba T. Unified-Hydrophilic-Interaction/Anion-Exchange Liquid Chromatography Mass Spectrometry (Unified-HILIC/AEX/MS): A Single-Run Method for Comprehensive and Simultaneous Analysis of Polar Metabolome. Anal Chem 2022

Nagae M, Hirata T, Tateno H, Mishra SK, Manabe N, Osada N, Tokoro Y, Yamaguchi Y, Doerksen RJ, Shimizu T, Kizuka Y. Discovery of a lectin domain that regulates enzyme activity in mouse N-acetylglucosaminyltransferase-IVa (MGAT4A). Commun Biol 2022

Murakami T, Takahata Y, Hata K, Ebina K, Hirose K, Ruengsinpinya L, Nakaminami Y, Etani Y, Kobayashi S, Maruyama T, Nakano H, Kaneko T, Toyosawa S, Asahara H, Nishimura R. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Sci Signal 2022

Morita K, Wada M, Nakatani K, Matsumoto Y, Hayashi N, Yamahata I, Mitsunari K, Mukae N, Takahashi M, Izumi Y, Bamba T, Shirane M. PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy. iScience 2022

Mizuno R, Hojo H, Takahashi M, Kashio S, Enya S, Nakao M, Konishi R, Yoda M, Harata A, Hamanishi J, Kawamoto H, Mandai M, Suzuki Y, Miura M, Bamba T, Izumi Y, Kawaoka S. Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase. Nat Commun 2022

Miyata Y, Yamada K, Nagata S, Segawa K. Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes. J Biol Chem 2022

Miyata Y, Segawa K. Protocol to analyze lipid asymmetry in the plasma membrane. STAR Protoc 2022

Miyake K, Shibata T, Fukui R, Sato R, Saitoh SI, Murakami Y. Nucleic Acid Sensing by Toll-Like Receptors in the Endosomal Compartment. Front Immunol 2022

Mise S, Matsumoto A, Shimada K, Hosaka T, Takahashi M, Ichihara K, Shimizu H, Shiraishi C, Saito D, Suyama M, Yasuda T, Ide T, Izumi Y, Bamba T, Kimura-Someya T, Shirouzu M, Miyata H, Ikawa M, Nakayama KI. Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nat Commun 2022

Michelson DA, Hase K, Kaisho T, Benoist C, Mathis D. Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells. Cell 2022

Matsumaru T, Sueyoshi K, Okubo K, Fujii S, Sakuratani K, Saito R, Ueki K, Yamasaki S, Fujimoto Y. Trehalose diesters containing a polar functional group-modified lipid moiety: Synthesis and evaluation of Mincle-mediated signaling activity. Bioorg Med Chem 2022

Manthrirathna M, Dangerfield EM, Ishizuka S, Woods A, Luong BS, Yamasaki S, Timmer MSM, Stocker BL. Water-soluble trehalose glycolipids show superior Mincle binding and signaling but impaired phagocytosis and IL-1beta production. Front Mol Biosci 2022

Lu X, Yamasaki S. Current understanding of T cell immunity against SARS-CoV-2. Inflamm Regen 2022

Leibler C, John S, Elsner RA, Thomas KB, Smita S, Joachim S, Levack RC, Callahan DJ, Gordon RA, Bastacky S, Fukui R, Miyake K, Gingras S, Nickerson KM, Shlomchik MJ. Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus. Nat Immunol 2022

Kunduri G, Le SH, Baena V, Vijaykrishna N, Harned A, Nagashima K, Blankenberg D, Izumi Y, Narayan K, Bamba T, Acharya U, Acharya JK. Delivery of ceramide phosphoethanolamine lipids to the cleavage furrow through the endocytic pathway is essential for male meiotic cytokinesis. PLoS Biol 2022

Koyama-Nasu R, Wang Y, Hasegawa I, Endo Y, Nakayama T, Kimura MY. The cellular and molecular basis of CD69 function in anti-tumor immunity. Int Immunol 2022

Konya Y, Izumi Y, Hamase K, Bamba T. Ultrafast simultaneous chiral analysis of native amino acid enantiomers using supercritical fluid chromatography/tandem mass spectrometry. J Chromatogr A 2022

Kobayashi H, Kimura MY, Hasegawa I, Suganuma E, Ikehara Y, Azuma K, Ito T, Ebata R, Kurashima Y, Kawasaki Y, Shiko Y, Saito N, Iwase H, Lee Y, Noval Rivas M, Arditi M, Zuka M, Hamada H, Nakayama T. Increased Myosin light chain 9 expression during Kawasaki disease vasculitis. Front Immunol 2022

Kawata M, Teramura T, Ordoukhanian P, Head SR, Natarajan P, Sundaresan A, Olmer M, Asahara H, Lotz MK. Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis. Ann Rheum Dis 2022

Iwamura C, Hirahara K, Kiuchi M, Ikehara S, Azuma K, Shimada T, Kuriyama S, Ohki S, Yamamoto E, Inaba Y, Shiko Y, Aoki A, Kokubo K, Hirasawa R, Hishiya T, Tsuji K, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Tsukamoto T, Nakamura S, Urushibara T, Kaneda S, Sakao S, Tobiume M, Suzuki Y, Tsujiwaki M, Kubo T, Hasegawa T, Nakase H, Nishida O, Takahashi K, Baba K, Izumi Y, Okazaki T, Kimura MY, Yoshino I, Igari H, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Ikehara Y, Yokote K, Nakayama T. Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2–induced lung exudative vasculitis and predicts COVID-19 severity. Proc Natl Acad Sci U S A 2022

Inuki S, Tabuchi H, Matsuzaki C, Yonejima Y, Hisa K, Kimura I, Yamamoto K, Ohno H. Chemical Synthesis and Evaluation of Exopolysaccharide Fragments Produced by Leuconostoc mesenteroides Strain NTM048. Chem Pharm Bull (Tokyo) 2022

Hirota T, Yagi M, Miller S, Nagai Y, Inuki S, Sato A. A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins. F1000Research 2022

Haji S, Ito T, Guenther C, Nakano M, Shimizu T, Mori D, Chiba Y, Tanaka M, Mishra SK, Willment JA, Brown GD, Nagae M, Yamasaki S. Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2. Elife 2022

Fujita S, Karasawa Y, Fujii M, Hironaka KI, Uda S, Kubota H, Inoue H, Sumitomo Y, Hirayama A, Soga T, Kuroda S. Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans. NPJ Syst Biol Appl 2022

Fujimoto K, Nakajima A, Hori S, Tanaka Y, Shirasaki Y, Uemura S, Irie N. Whole-embryonic identification of maternal microchimeric cell types in mouse using single-cell RNA sequencing. Sci Rep 2022

English K, Tan SY, Kwan R, Holz LE, Sierro F, McGuffog C, Kaisho T, Heath WR, MacDonald KPA, McCaughan GW, Bowen DG, Bertolino P. The liver contains distinct interconnected networks of CX3CR1+ macrophages, XCR1+ type 1 and CD301a+ type 2 conventional dendritic cells embedded within portal tracts. Immunol Cell Biol 2022

Badrinath S, Dellacherie MO, Li A, Zheng S, Zhang X, Sobral M, Pyrdol JW, Smith KL, Lu Y, Haag S, Ijaz H, Connor-Stroud F, Kaisho T, Dranoff G, Yuan GC, Mooney DJ, Wucherpfennig KW. A vaccine targeting resistant tumours by dual T cell plus NK cell attack. Nature 2022

Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U. Structure of the bile acid transporter and HBV receptor NTCP. Nature 2022

Alcantara MC, Suzuki K, Acebedo AR, Kajioka D, Hirohata S, Kaisho T, Hatano Y, Yamagata K, Takahashi S, Yamada G. Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice. iScience 2022

Akita S, Ikehara Y, Arai M, Tokumoto H, Yamaji Y, Azuma K, Kubota Y, Haneishi H, Kimura MY, Mitsukawa N. Clinical and Histological Effects of Partial Blood Flow Impairment in Vascularized Lymph Node Transfer. J Clin Med 2022

Ishihara, N., Y. Nakamura, K. Yakabe, S. Komiyama, Y. Fujimura, T. Kaisho, S. Kimura, K. Hase. Spi-B alleviates food allergy by securing mucosal barrier and immune tolerance in the intestine. Front Allergy 2022